Matthias Dobbelstein researcher
Dobbelstein, Matthias
VIAF ID: 9813161763145822560007 (Personal)
Permalink: http://viaf.org/viaf/9813161763145822560007
Preferred Forms
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100 1 _
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Dobbelstein, Matthias
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100 0 _
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Matthias Dobbelstein
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researcher
4xx's: Alternate Name Forms (4)
5xx's: Related Names (1)
Works
| Title | Sources |
|---|---|
| 5-Fluorouracil sensitizes colorectal tumor cells towards double stranded DNA breaks by interfering with homologous recombination repair |
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| Activating Ras mutations fail to ensure efficient replication of adenovirus mutants lacking VA-RNA. |
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| Adenovirus E1-transformed cells grow despite the continuous presence of transcriptionally active p53. |
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| Adenovirus-induced extracellular signal-regulated kinase phosphorylation during the late phase of infection enhances viral protein levels and virus progeny |
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| The alpha/beta carboxy-terminal domains of p63 are required for skin and limb development. New insights from the Brdm2 mouse which is not a complete p63 knockout but expresses p63 gamma-like proteins |
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| Anthracyclines induce the accumulation of mutant p53 through E2F1-dependent and -independent mechanisms |
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| Bcl-xL mediates therapeutic resistance of a mesenchymal breast cancer cell subpopulation. |
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| BRCA1 and Tip60 determine the cellular response to ultraviolet irradiation through distinct pathways |
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| Brdm2 - an aberrant hypomorphic p63 allele |
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| The CDK4/6-EZH2 pathway is a potential therapeutic target for psoriasis |
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| Chromatin modifiers Mdm2 and RNF2 prevent RNA:DNA hybrids that impair DNA replication |
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| Comprehensive identification of genes driven by ERV9-LTRs reveals TNFRSF10B as a re-activatable mediator of testicular cancer cell death |
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| Damage-induced DNA replication stalling relies on MAPK-activated protein kinase 2 activity |
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| DeltaNp73 can modulate the expression of various genes in a p53-independent fashion |
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| Differential regulation of p63 and p73 expression |
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| Dipeptidyl peptidase 9 triggers BRCA2 degradation and promotes DNA damage repair |
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| Direct p53 transcriptional repression: in vivo analysis of CCAAT-containing G2/M promoters. |
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| Doxorubicin-induced activation of NF-κB in melanoma cells is abrogated by inhibition of IKKβ, but not by a novel IKKα inhibitor |
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| Dysfunctional p53 deletion mutants in cell lines derived from Hodgkin's lymphoma |
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| E1A genes of adenovirus type 2 and type 5 are expressed at different levels |
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| E1B 55-kilodalton oncoproteins of adenovirus types 5 and 12 inactivate and relocalize p53, but not p51 or p73, and cooperate with E4orf6 proteins to destabilize p53. |
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| E1B-55-kilodalton protein is not required to block p53-induced transcription during adenovirus infection |
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| E2F1-inducible microRNA 449a/b suppresses cell proliferation and promotes apoptosis |
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| Efficient replication of adenovirus despite the overexpression of active and nondegradable p53. |
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| Endothelial p53 deletion improves angiogenesis and prevents cardiac fibrosis and heart failure induced by pressure overload in mice |
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| Enhanced cytotoxicity without internuclear spread of adenovirus upon cell fusion by measles virus glycoproteins. |
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| Exploiting replicative stress to treat cancer |
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| Export of hepatitis B virus RNA on a Rev-like pathway: inhibition by the regenerating liver inhibitory factor IkappaB alpha. |
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| HER2/ErbB2 activates HSF1 and thereby controls HSP90 clients including MIF in HER2-overexpressing breast cancer |
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| HSP90 inhibitor antagonizing MIF: The specifics of pleiotropic cancer drug candidates |
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| Identification of a microRNA expression signature for chemoradiosensitivity of colorectal cancer cells, involving miRNAs-320a, -224, -132 and let7g. |
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| Immunofluorescence-based screening identifies germ cell associated microRNA 302 as an antagonist to p63 expression |
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| Improving survival by exploiting tumour dependence on stabilized mutant p53 for treatment |
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| In vitro selection of RNA ligands for the ribosomal L22 protein associated with Epstein-Barr virus-expressed RNA by using randomized and cDNA-derived RNA libraries |
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| Inactivation of the p53-homologue p73 by the mdm2-oncoprotein |
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| Infection with E1B-mutant adenovirus stabilizes p53 but blocks p53 acetylation and activity through E1A. |
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| Inhibiting the HSP90 chaperone destabilizes macrophage migration inhibitory factor and thereby inhibits breast tumor progression |
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| Inhibition of MAPKAPK2/MK2 facilitates DNA replication upon cancer cell treatment with gemcitabine but not cisplatin |
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| Interchanging heads: p53 re-composes the DREAM/MMB complex to repress transcription |
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| Intracistronic complementation reveals a new function of SV40 T antigen that co-operates with Rb and p53 binding to stimulate DNA synthesis in quiescent cells |
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| A killer promoting survival: p53 as a selective means to avoid side effects of chemotherapy |
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| The large T antigen of simian virus 40 binds and inactivates p53 but not p73. |
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| The MAPK-activated protein kinase 2 mediates gemcitabine sensitivity in pancreatic cancer cells |
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| MDM2 Associates with Polycomb Repressor Complex 2 and Enhances Stemness-Promoting Chromatin Modifications Independent of p53 |
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| MDM2 binds and ubiquitinates PARP1 to enhance DNA replication fork progression |
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| Mdm2 inhibition confers protection of p53-proficient cells from the cytotoxic effects of Wee1 inhibitors |
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| The MDM2 oncoprotein binds specifically to RNA through its RING finger domain |
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| Mdm2 - open questions |
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| MicroRNA-101 Suppresses Tumor Cell Proliferation by Acting as an Endogenous Proteasome Inhibitor via Targeting the Proteasome Assembly Factor POMP. |
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| MicroRNA-449a levels increase by several orders of magnitude during mucociliary differentiation of airway epithelia |
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| Mutual interference of adenovirus infection and myc expression |
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| Neutralization of SARS-CoV-2 by highly potent, hyperthermostable, and mutation-tolerant nanobodies |
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| NF-Y dependent epigenetic modifications discriminate between proliferating and postmitotic tissue |
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| Non-hominid TP63 lacks retroviral LTRs but contains a novel conserved upstream exon. |
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| Nongenotoxic p53 activation protects cells against S-phase-specific chemotherapy |
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| The nuclear export signal within the E4orf6 protein of adenovirus type 5 supports virus replication and cytoplasmic accumulation of viral mRNA. |
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| Nucleo-cytoplasmic shuttling of the hdm2 oncoprotein regulates the levels of the p53 protein via a pathway used by the human immunodeficiency virus rev protein. |
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| Overcoming EMT-driven therapeutic resistance by BH3 mimetics |
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| p21/CDKN1A mediates negative regulation of transcription by p53. |
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| p53 induces the expression of its antagonist p73 Delta N, establishing an autoregulatory feedback loop |
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| p53-Responsive micrornas 192 and 215 are capable of inducing cell cycle arrest |
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| p63 antagonizes Wnt-induced transcription |
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| p73 and p63: why do we still need them? |
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| p73 is an essential regulator of neural stem cell maintenance in embryonal and adult CNS neurogenesis |
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| A polymorphic microsatellite that mediates induction of PIG3 by p53. |
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| A pro-apoptotic function of iASPP by stabilizing p300 and CBP through inhibition of BRMS1 E3 ubiquitin ligase activity |
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| A promoter that acquired p53 responsiveness during primate evolution |
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| Protection against apoptosis by the vaccinia virus SPI-2 (B13R) gene product |
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| Reactivation of mutant p53 by a one-hybrid adaptor protein. |
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| Rev protein of human immunodeficiency virus type 1 and cellular exportin 1 protein relocalize each other to a subnucleolar structure |
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| Screening analysis of ubiquitin ligases reveals G2E3 as a potential target for chemosensitizing cancer cells |
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| Self-association of adenovirus type 5 E1B-55 kDa as well as p53 is essential for their mutual interaction. |
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| TAp73 is essential for germ cell adhesion and maturation in testis. |
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| Targeting tumour-supportive cellular machineries in anticancer drug development |
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| Telethonin deficiency is associated with maladaptation to biomechanical stress in the mammalian heart |
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| Tumor-derived mutations within the DNA-binding domain of p53 that phenotypically resemble the deletion of the proline-rich domain |
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| UDP glucuronosyltransferase 1A expression levels determine the response of colorectal cancer cells to the heat shock protein 90 inhibitor ganetespib |
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| Usp22 deficiency impairs intestinal epithelial lineage specification in vivo |
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| Viral and cellular factors that target the promyelocytic leukemia oncogenic domains strongly activate a glucocorticoid-responsive promoter |
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| Wee1 and Chk1 - crosstalk between key players in replicative stress |
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| Wee1 is required to sustain ATR/Chk1 signaling upon replicative stress |
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| While p73 is essential, p63 is completely dispensable for the development of the central nervous system |
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| YB-1 relocates to the nucleus in adenovirus-infected cells and facilitates viral replication by inducing E2 gene expression through the E2 late promoter |
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