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Frank J. Dekker Wikidata

Dekker, Frank J. German National Library

VIAF ID: 4961153954899805680004 (Personal)

Permalink: http://viaf.org/viaf/4961153954899805680004

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Amino propynyl benzoic acid building block in rigid spacers of divalent ligands binding to the Syk SH2 domains with equally high affinity as the natural ligand. Wikidata
Aqueous oxidative Heck reaction as a protein-labeling strategy. Wikidata
Binding of a diphosphorylated-ITAM peptide to spleen tyrosine kinase (Syk) induces distal conformational changes: a hydrogen exchange mass spectrometry study. Wikidata
Catalytic asymmetric total synthesis of (S)-(-)-zearalenone, a novel lipoxygenase inhibitor. Wikidata
Characterization of a thermostable methylaspartate ammonia lyase from Carboxydothermus hydrogenoformans. Wikidata
Design of compound libraries based on natural product scaffolds and protein structure similarity clustering (PSSC). Wikidata
Development of highly potent inhibitors of the Ras-targeting human acyl protein thioesterases based on substrate similarity design. Wikidata
Discovery of a novel activator of 5-lipoxygenase from an anacardic acid derived compound collection. Wikidata
A dual inhibitor of matrix metalloproteinases and a disintegrin and metalloproteinases, [¹⁸F]FB-ML5, as a molecular probe for non-invasive MMP/ADAM-targeted imaging. Wikidata
Engineering methylaspartate ammonia lyase for the asymmetric synthesis of unnatural amino acids Wikidata
A functional screen implicates microRNA-138-dependent regulation of the depalmitoylation enzyme APT1 in dendritic spine morphogenesis. Wikidata
The histone acetyltransferase p300 inhibitor C646 reduces pro-inflammatory gene expression and inhibits histone deacetylases. Wikidata
Histone deacetylase 3 (HDAC 3) as emerging drug target in NF-κB-mediated inflammation Wikidata
Identification of 6-benzyloxysalicylates as a novel class of inhibitors of 15-lipoxygenase-1. Wikidata
Increased acetylation of lysine 317/320 of p53 caused by BCR-ABL protects from cytoplasmic translocation of p53 and mitochondria-dependent apoptosis in response to DNA damage. Wikidata
Inflammation, Cancer and Oxidative Lipoxygenase Activity are Intimately Linked. Wikidata
Inhibiting the palmitoylation/depalmitoylation cycle selectively reduces the growth of hematopoietic cells expressing oncogenic Nras Wikidata
Inhibition of PCAF by anacardic acid derivative leads to apoptosis and breaks resistance to DNA damage in BCR-ABL-expressing cells. Wikidata
Light-Controlled Histone Deacetylase (HDAC) Inhibitors: Towards Photopharmacological Chemotherapy. Wikidata
Photoactivation provides a mechanistic explanation for pan-assay interference behaviour of 2-aminopyrroles in lipoxygenase inhibition. Wikidata
The Process and Strategy for Developing Selective Histone Deacetylase 3 Inhibitors. Wikidata
Protein flexibility and ligand rigidity: a thermodynamic and kinetic study of ITAM-based ligand binding to Syk tandem SH2. Wikidata
Raft protein clustering alters N-Ras membrane interactions and activation pattern. Wikidata
Reactivity of isothiazolones and isothiazolone-1-oxides in the inhibition of the PCAF histone acetyltransferase. Wikidata
Role of solution conformation and flexibility of short peptide ligands that bind to the p56(lck) SH2 domain. Wikidata
Site-specific quantification of lysine acetylation in the N-terminal tail of histone H4 using a double-labelling, targeted UHPLC MS/MS approach Wikidata
Small-molecule inhibition of APT1 affects Ras localization and signaling Wikidata
Small Multitarget Molecules Incorporating the Enone Moiety Wikidata
Surface plasmon resonance thermodynamic and kinetic analysis as a strategic tool in drug design. Distinct ways for phosphopeptides to plug into Src- and Grb2 SH2 domains. Wikidata
Towards the development of activity-based probes for detection of lysine-specific demethylase-1 activity. Wikidata

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