Reinheckel, Thomas 1967-
Thomas Reinheckel researcher
Reinheckel, Thomas
VIAF ID: 42658273 (Personal)
Permalink: http://viaf.org/viaf/42658273
Preferred Forms
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100 1 _ ‡a Reinheckel, Thomas
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100 1 _ ‡a Reinheckel, Thomas ‡d 1967-
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100 1 _ ‡a Reinheckel, Thomas ‡d 1967-
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100 0 _ ‡a Thomas Reinheckel ‡c researcher
4xx's: Alternate Name Forms (1)
5xx's: Related Names (2)
Works
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Apoptosis induced by selective lysosome membrane permeabilization proceeds through mitochondrial destabilization and its largely dependent on cathepsins B and L |
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Cathepin inhibition for cancer therapy? : lessons from mouse models |
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Cathepsin B as a potential cystatin M/E target in the mouse hair follicle |
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Cathepsin B promotes histopathological progression and proliferatino of mammary cancer |
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Cathepsin D deficiency in mammary epithelium transiently stalls breast cancer by interference with mTORC1 signaling |
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Cathepsin D regulates cathepsin B activation and disease severity predominantly in inflammatory cells during experimental pancreatitis |
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Co-targeting human mammary cancer cells with kinase- and protease-inhibitors |
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Combinatorial omics analysis reveals perturbed lysosomal homeostasis in collagen VII-deficient keratinocytes |
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Conditional gene targeting reveals cell type-specific roles of the lysosomal protease cathepsin L in mammary tumor progression |
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CTSH regulates β-cell function and disease progression in newly diagnosed type 1 diabetes patients |
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The death receptor pathway and the involvement of lysosomes |
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Decreased arthritis severity in cathepsin L-deficient mice is attributed to an impaired T helper cell compartment |
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Degradation of oxidized proteins in mammalian cells. |
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Differential Impact of cysteine cathepsins on genetic mouse models of de novo carcinogenesis: cathepsin B as emerging therapeutic target |
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Differential impairment of 20S and 26S proteasome activities in human hematopoietic K562 cells during oxidative stress |
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Differential regulation of progranulin derived granulin peptides |
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Dipeptidyl-peptidase 9 regulates the dynamics of tumorigenesis and metastasis in breast cancer |
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Discordance in cathepsin B and cystatin C expressions in bronchoalveolar fluids between murine bleomycin-induced fibrosis and human idiopathic fibrosis. |
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Distinct functions of macrophage-derived and cancer cell-derived cathepsin Z combine to promote tumor malignancy via interactions with the extracellular matrix. |
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DPP9 substrates in DNA damage repair |
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Ferri-liposomes as an MRI-visible drug-delivery system for targeting tumours and their microenvironment |
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Genetic cathepsin B deficiency reduces beta-amyloid in transgenic mice expressing human wild-type amyloid precursor protein |
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Human and mouse perforin are processed in part through cleavage by the lysosomal cysteine proteinase cathepsin L. |
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The human cysteine protease cathepsin V can compensate for murine cathepsin L in mouse epidermis and hair follicles. |
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Impact of cathepsin B on the interstitial fluid proteome of murine breast cancers |
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Impact of proteolysis on cancer stem cell functions |
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In vivo metabolic imaging of [1‐13C]pyruvate‐d3 hyperpolarized by reversible exchange with parahydrogen |
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Induction of premalignant host responses by cathepsin x/z-deficiency in Helicobacter pylori-infected mice. |
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Intracellular cathepsin C levels determine sensitivity of cells to leucyl-leucine methyl ester-triggered apoptosis |
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Legumain as a modulator of immune response |
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Legumain is activated in macrophages during pancreatitis |
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Low level lysosomal membrane permeabilization for limited release and sub‐lethal functions of cathepsin proteases in the cytosol and nucleus |
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The lysosomal cysteine protease cathepsin L regulates keratinocyte proliferation by control of growth factor recycling. |
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Lysosomal damage drives mitochondrial proteome remodelling and reprograms macrophage immunometabolism |
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Lysosomal processing of progranulin |
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Lysosomal protease deficiency or substrate overload induces an oxidative-stress mediated STAT3-dependent pathway of lysosomal homeostasis |
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Lysosomal protein turnover contributes to the acquisition of TGFβ-1 induced invasive properties of mammary cancer cells |
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Magnetoliposome delivered cysteine cathepsin inhibitor JPM-565 inhibits growth of mammary tumour lesions |
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Major role of cathepsin L for producing the peptide hormones ACTH, beta-endorphin, and alpha-MSH, illustrated by protease gene knockout and expression |
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A mechanistic target of rapamycin complex 1/2 (mTORC1)/V-Akt murine thymoma viral oncogene homolog 1 (AKT1)/cathepsin H axis controls filaggrin expression and processing in skin, a novel mechanism for skin barrier disruption in patients with atopic d |
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MMP14 empowers tumor-initiating breast cancer cells under hypoxic nutrient-depleted conditions |
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Molecular characterization of arylsulfatase G: expression, processing, glycosylation, transport, and activity |
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Monitoring the modulation of protein-protein interactions within the USP18-ISG15 system using Bioluminescence Resonance Energy Transfer (BRET) |
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Murine and human cathepsin B exhibit similar properties: possible implications for drug discovery |
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Neuronal-specific microexon splicing of TAF1 mRNA is directly regulated by SRRM4/nSR100 |
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Neutrophil and alveolar macrophage-mediated innate immune control of legionella pneumophila lung infection via TNF and ROS |
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New kid on the block |
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Occurrence of oxidatively modified proteins: an early event in experimental acute pancreatitis |
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On the road to inflammation: linking lysosome disruption, lysosomal protease release and necrotic death of immune cells |
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Oxidative stress affects pancreatic proteins during the early pathogenesis of rat caerulein pancreatitis |
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Oxidative stress in lung tissue induced by CO(2) pneumoperitoneum in the rat |
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Phosphoproteomic analysis of legumain deficient mice |
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The PI3K regulatory subunits p55α and p50α regulate cell death in vivo. |
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Profiling trait anxiety: transcriptome analysis reveals cathepsin B (Ctsb) as a novel candidate gene for emotionality in mice |
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Proteolysis-a characteristic of tumor-initiating cells in murine metastatic breast cancer |
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Proteomic analysis of lung metastases in a murine breast cancer model reveals divergent influence of CTSB and CTSL overexpression |
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Proteomic identification of legumain physiological substrates |
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Reduced tumour cell proliferation and delayed development of high-grade mammary carcinomas in cathepsin B-deficient mice |
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RNA interference screens discover proteases as synthetic lethal partners of PI3K inhibition in breast cancer cells |
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A role for cathepsin E in the processing of mast-cell carboxypeptidase A. |
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A role for cathepsin Z in neuroinflammation provides mechanistic support for an epigenetic risk factor in multiple sclerosis |
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Role of cathepsins in TRAIL-induced apoptosis |
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Role of cysteine cathepsins in the mechanisms of mammary cancer progression inthe PyMT mouse model with different cathepsin B genotypes |
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Role of endogenous and exogenous antioxidants in the defence against functional damage and lipid peroxidation in rat liver mitochondria |
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The role of stefin B depletion in mammary tumor progression and metastatis |
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secreted inhibitor of invasive cell growth CREG1 is negatively regulated by cathepsin proteases |
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Single nephron proteomes connect morphology and function in proteinuric kidney disease. |
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Spatially and temporally defined lysosomal leakage facilitates mitotic chromosome segregation |
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Specialized roles for cysteine cathepsins in health and disease. |
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Stefin B deficiency reduces tumor growth via sensitization of tumor cells to oxidative stress in a breast cancer model. |
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Studies of intestinal morphology and cathepsin B expression in a transgenic mouse aiming at intestine-specific expression of Cath B-EGFP. |
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Transgenic expression of human cathepsin B promotes progression and metastasis of polyoma-middle-T-induced breast cancer in mice |
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Trial of the cysteine cathepsin inhibitor JPM-OEt on early and advanced mammary cancer stages in the MMTV-PyMT-transgenic mouse model. |
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Unconventional trafficking of mammalian phospholipase D3 to lysosomes |
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Unimpeded skin carcinogenesis in K14-HPV16 transgenic mice deficient for plasminogen activator inhibitor. |
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Vloga lizosomov pri apoptozi sproženi z ligandom TRAIL |
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Zelltyp-spezifische physiologische und pathologische Funktionen der lysosomalen Proteasen Cathepsin B und Cathepsin L |
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