Ian Tomlinson Director of the Institute of Cancer and Genomic Sciences at the University of Birmingham
Tomlinson, Ian
VIAF ID: 316463491 (Personal)
Permalink: http://viaf.org/viaf/316463491
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Works
| Title | Sources |
|---|---|
| Corrigendum: Whole-genome sequencing of bladder cancers reveals somatic CDKN1A mutations and clinicopathological associations with mutation burden |
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| Deciphering the 8q24.21 association for glioma |
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| Deciphering the genetics of hereditary non-syndromic colorectal cancer |
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| Defects in mismatch repair occur after APC mutations in the pathogenesis of sporadic colorectal tumours |
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| Definition of a minimal region of deletion of chromosome 7 in uterine leiomyomas by tiling-path microarray CGH and mutation analysis of known genes in this region |
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| Deletion at chromosome band 20p12.1 in colorectal cancer revealed by high resolution array comparative genomic hybridization |
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| Detailed Molecular and Immune Marker Profiling of Archival Prostate Cancer Samples Reveals an Inverse Association between TMPRSS2:ERG Fusion Status and Immune Cell Infiltration |
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| Detecting low penetrance genes in cancer: the way ahead |
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| Detecting repeated cancer evolution from multi-region tumor sequencing data |
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| Different APC genotypes in proximal and distal sporadic colorectal cancers suggest distinct WNT/β-catenin signalling thresholds for tumourigenesis. |
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| Differential clonal evolution in oesophageal cancers in response to neo-adjuvant chemotherapy |
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| DNA copy-number alterations underlie gene expression differences between microsatellite stable and unstable colorectal cancers |
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| DNA microarrays for comparative genomic hybridization based on DOP-PCR amplification of BAC and PAC clones |
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| DNA mismatch repair in lymphoblastoid cells from hereditary non-polyposis colorectal cancer (HNPCC) patients is normal under conditions of rapid cell division and increased mutational load. |
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| DNA polymerase ε and δ exonuclease domain mutations in endometrial cancer |
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| Does MSI-low exist? |
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| Down-regulation of serum/glucocorticoid regulated kinase 1 in colorectal tumours is largely independent of promoter hypermethylation |
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| E-cadherin/catenin complex status in solid pseudopapillary tumor of the pancreas |
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| Ectopic expression of P-cadherin correlates with promoter hypomethylation early in colorectal carcinogenesis and enhanced intestinal crypt fission in vivo. |
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| Enrichment of low penetrance susceptibility loci in a Dutch familial colorectal cancer cohort |
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| EPHB2 germline variants in patients with colorectal cancer or hyperplastic polyposis |
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| Erratum: A new GWAS and meta-analysis with 1000Genomes imputation identifies novel risk variants for colorectal cancer |
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| Erratum: COGENT (COlorectal cancer GENeTics): an international consortium to study the role of polymorphic variation on the risk of colorectal cancer |
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| Erratum: Corrigendum: Common variants at 19p13 are associated with susceptibility to ovarian cancer |
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| Erratum: Corrigendum: Replication stress links structural and numerical cancer chromosomal instability |
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| Erratum: Germline mutations affecting the proofreading domains of POLE and POLD1 predispose to colorectal adenomas and carcinomas |
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| Erratum to: Genetic Biomarkers of Barrett's Esophagus Susceptibility and Progression to Dysplasia and Cancer: A Systematic Review and Meta-Analysis |
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| Evaluation of association of HNF1B variants with diverse cancers: collaborative analysis of data from 19 genome-wide association studies |
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| Evaluation of PIK3CA mutation as a predictor of benefit from nonsteroidal anti-inflammatory drug therapy in colorectal cancer |
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| An evaluation of the clinical utility of a panel of variants in DPYD and ENOSF1 for predicting common capecitabine related toxicities |
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| Evaluation of variation in the phosphoinositide-3-kinase catalytic subunit alpha oncogene and breast cancer risk |
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| Evidence against a major genetic basis for combined breast and colorectal cancer susceptibility |
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| Evidence for a colorectal cancer susceptibility locus on chromosome 3q21–q24 from a high-density SNP genome-wide linkage scan |
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| Evidence for an association between compound heterozygosity for germ line mutations in the hemochromatosis |
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| Evidence for genetic association between chromosome 1q loci and predisposition to colorectal neoplasia |
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| Evidence for genetic predisposition to desmoid tumours in familial adenomatous polyposis independent of the germline APC mutation |
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| Evidence of increased microvessel density and activation of the hypoxia pathway in tumours from the hereditary leiomyomatosis and renal cell cancer syndrome |
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| Evidence of Linkage to Chromosome 9q22.33 in Colorectal Cancer Kindreds from the United Kingdom |
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| Evidence that breast cancer risk at the 2q35 locus is mediated through IGFBP5 regulation |
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| Evolutionary history of human colitis-associated colorectal cancer |
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| Exclusion of PTEN and 10q22-24 as the susceptibility locus for juvenile polyposis syndrome |
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| Exome sequencing of osteosarcoma reveals mutation signatures reminiscent of BRCA deficiency |
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| Exon 3 beta-catenin mutations are specifically associated with colorectal carcinomas in hereditary non-polyposis colorectal cancer syndrome |
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| Explaining variation in familial adenomatous polyposis: relationship between genotype and phenotype and evidence for modifier genes |
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| Exploiting differential Wnt target gene expression to generate a molecular biomarker for colorectal cancer stratification |
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| Exploring causality in the association between circulating 25-hydroxyvitamin D and colorectal cancer risk: a large Mendelian randomisation study |
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| Expression of EGFR, HER2, phosphorylated ERK and phosphorylated MEK in colonic neoplasms of familial adenomatous polyposis patients |
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| Expression of HIF-1alpha, HIF-2alpha (EPAS1), and their target genes in paraganglioma and pheochromocytoma with VHL and SDH mutations. |
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| Expression of Idh1(R132H) in the Murine Subventricular Zone Stem Cell Niche Recapitulates Features of Early Gliomagenesis |
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| Expression of the cancer-associated DNA polymerase ε P286R in fission yeast leads to translesion synthesis polymerase dependent hypermutation and defective DNA replication |
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| Expression profiling in progressive stages of fumarate-hydratase deficiency: the contribution of metabolic changes to tumorigenesis |
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| F-box and WD repeat domain-containing 7 regulates intestinal cell lineage commitment and is a haploinsufficient tumor suppressor |
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| Factors influencing success of clinical genome sequencing across a broad spectrum of disorders |
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| Failure of programmed cell death and differentiation as causes of tumors: some simple mathematical models |
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| Familial adenomatous polyposis and the small bowel: a loco-regional review and current management strategies |
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| A family with juvenile polyposis linked to the BMPR1A locus: cryptic mutation or closely linked gene? |
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| FBXW7 influences murine intestinal homeostasis and cancer, targeting Notch, Jun, and DEK for degradation |
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| FBXW7-mutated colorectal cancer cells exhibit aberrant expression of phosphorylated-p53 at Serine-15. |
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| FBXW7 mutations typically found in human cancers are distinct from null alleles and disrupt lung development |
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| An FBXW7-ZEB2 axis links EMT and tumour microenvironment to promote colorectal cancer stem cells and chemoresistance |
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| FGF receptor genes and breast cancer susceptibility: results from the Breast Cancer Association Consortium |
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| Fine-mapping identifies two additional breast cancer susceptibility loci at 9q31.2. |
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| A genome-wide association study on copy-number variation identifies a 11q11 loss as a candidate susceptibility variant for colorectal cancer. |
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| A genome-wide association study shows that common alleles of SMAD7 influence colorectal cancer risk |
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| An intergenic risk locus containing an enhancer deletion in 2q35 modulates breast cancer risk by deregulating IGFBP5 expression |
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| A large-scale meta-analysis to refine colorectal cancer risk estimates associated with MUTYH variants |
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| A mitotic recombination map proximal to the APC locus on chromosome 5q and assessment of influences on colorectal cancer risk |
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| A modifying locus for familial adenomatous polyposis may be present on chromosome 1p35-p36 |
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| A network analysis to identify mediators of germline-driven differences in breast cancer prognosis |
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| A nonlinear mathematical model of cell turnover, differentiation and tumorigenesis in the intestinal crypt. |
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| A novel test for gene-ancestry interactions in genome-wide association data |
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| A pericentric inversion of chromosome six in a patient with Peutz-Jeghers' syndrome and the use of FISH to localise the breakpoints on a genetic map |
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| A polymorphic enhancer near GREM1 influences bowel cancer risk through differential CDX2 and TCF7L2 binding |
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| A polymorphic p53 response element in KIT ligand influences cancer risk and has undergone natural selection |
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| A sensitive and affordable multiplex RT-qPCR assay for SARS-CoV-2 detection |
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| A serine/threonine kinase gene defective in Peutz-Jeghers syndrome |
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| A study of genomic instability in early preneoplastic colonic lesions. |
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