1D NMR WaterLOGSY as an efficient method for fragment-based lead discovery |
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2-Aminothiazole Derivatives as Selective Allosteric Modulators of the Protein Kinase CK2. 1. Identification of an Allosteric Binding Site |
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Binding evaluation of fragment-based scaffolds for probing allosteric enzymes. |
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Biochemical characterization and nuclear magnetic resonance structure of novel alpha-conotoxins isolated from the venom of Conus consors |
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The carboxyl-terminal region common to lamins A and C contains a DNA binding domain. |
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A coil-helix instead of a helix-coil motif can be induced in a chloroplast transit peptide from Chlamydomonas reinhardtii |
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Crystal structure and solution NMR dynamics of a D (type II) peroxiredoxin glutaredoxin and thioredoxin dependent: a new insight into the peroxiredoxin oligomerism. |
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Design of small molecule ligands for the study of the VDAC1 protein. |
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Design, synthèse et caractérisation d'inhibiteurs d'hélicase Pif1 et BLM |
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Development of new technologies for healthcare based on Tritium NMR. |
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Développement de nouvelles technologies pour la santé autour de la RMN du Tritium |
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Développement d'inhibiteurs de la protéine kinase CK2 ciblant l'interaction α/β : conception, synthèse, étude mécanistique et effets cellulaires |
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Développement d'outils de chémoinformatique pour l'identification d'inhibiteurs de protéines kinases à partir de fragments |
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Développement et validation de petites molécules modulatrices de l'activité de la nucléoside kinase dCK. |
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Discovery of fragment molecules that bind the human peroxiredoxin 5 active site |
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Discovery of holoenzyme-disrupting chemicals as substrate-selective CK2 inhibitors |
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Enabling STD-NMR fragment screening using stabilized native GPCR: A case study of adenosine receptor. |
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Étude d’interactions protéines-petites molécules par Résonance Magnétique Nucléaire : application de la méthode des fragments à la conception d’inhibiteurs de protéine. |
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Étude par RMN de toxines animales et d'enzymes dépendantes de thiorédoxines |
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F-ara-AMP is a substrate of cytoplasmic 5'-nucleotidase II (cN-II): HPLC and NMR studies of enzymatic dephosphorylation |
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Fragment-based discovery of a new family of non-peptidic small-molecule cyclophilin inhibitors with potent antiviral activities |
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[Fragment-based screening: a promising avenue for drug design] |
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Glutathionylation Induces the Dissociation of 1-Cys D-peroxiredoxin Non-covalent Homodimer |
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Identification of Noncompetitive Inhibitors of Cytosolic 5'-Nucleotidase II Using a Fragment-Based Approach |
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Identifying Protein Allosteric Transitions for Drug Discovery with 1D NMR. |
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Letter to the Editor:1H,13C and15N resonance assignments of poplar phloem glutaredoxin |
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Ligand-Orientation Based Fragment Selection in STD NMR Screening |
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Ligand specificity, privileged substructures and protein druggability from fragment-based screening. |
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Méthodes RMN pour la découverte de nouveaux ligands ciblant les récepteurs couplés aux protéines G |
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Modification and Biological Evaluation of a Series of 1,5-Diaryl-1,2,4-triazole Compounds as Novel Agents against Pancreatic Cancer Metastasis through Targeting Myoferlin |
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NMR methods for G-protein coupled receptors drug discovery. |
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NMR screening applied to the fragment-based generation of inhibitors of creatine kinase exploiting a new interaction proximate to the ATP binding site. |
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NMR structures and activity of a novel alpha-like toxin from the scorpion Leiurus quinquestriatus hebraeus |
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NMR study of biological macromolecules : structural study of CGC-19, a single domain protein involved in the biosynthesis of congocidine, a secondary metabolite from Streptomyces Ambofaciens, NMR contribution to anti-apoptotic protein ligand development. |
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Overview of Probing Protein-Ligand Interactions Using NMR. |
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Probing protein-small molecule interactions by Nuclear Magnetic Resonance : towards a better understanding of the Fragment-Based Drug Design methodology |
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Protein-protein interactions within peroxiredoxin systems. |
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Quantitative analysis of chemical shift perturbations for the determination of protein-ligand complex tridimentional structures. |
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The single mutation Trp35-->Ala in the 35-40 redox site of Chlamydomonas reinhardtii thioredoxin h affects its biochemical activity and the pH dependence of C36-C39 1H-13C NMR. |
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Structural characterization of Plasmodium falciparum CTP : phosphocholine cytidylyltransferase and fragment-based drug design approach for targeting phospholipid biosynthesis pathway. |
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Sugars and astringency : effect of wine polysaccharides on the interactions between tannins and proteins. |
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