ANALYSE MOLECULAIRE DE L'ACIDE RETINOIQUE ET DE L'ARSENIC DANS LA LEUCEMIE AIGUE PROMYELOCYTAIRE |
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Cancer : l'arsenal des nouvelles thérapies. |
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CARACTERISATION DES EFFETS BIOLOGIQUES DE PML, UNE PROTEINE IMPLIQUEE DANS LA LEUCEMIE AIGUE PROMYELOCYTAIRE |
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The cell biology of disease: Acute promyelocytic leukemia, arsenic, and PML bodies |
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Centrosomal pre-integration latency of HIV-1 in quiescent cells |
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Characterization of the biological effects of the pml protein implicated in acute promyelocytic leukemia. |
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Ciblage thérapeutique de Tax et de la voie NF-kB dans la leucémie T de l' adulte liée au rétrovirus HTLV-I |
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Classic and Variants APLs, as Viewed from a Therapy Response |
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The combination of arsenic, interferon-alpha, and zidovudine restores an "immunocompetent-like" cytokine expression profile in patients with adult T-cell leukemia lymphoma. |
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Comment on "SUMO deconjugation is required for arsenic-triggered ubiquitylation of PML". |
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Controversies in targeted therapy of adult T cell leukemia/lymphoma: ON target or OFF target effects? |
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Critical involvement of the ATM-dependent DNA damage response in the apoptotic demise of HIV-1-elicited syncytia |
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Detection of Protein SUMOylation In Situ by Proximity Ligation Assays. |
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Differential sumolation of the two major PML sumoylation sites by sumo-1 and sumo-2. |
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Donor-derived oral squamous cell carcinoma after allogeneic bone marrow transplantation |
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The drug-induced degradation of oncoproteins: an unexpected Achilles' heel of cancer cells? |
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Effective targeting of chronic myeloid leukemia initiating activity with the combination of arsenic trioxide and interferon alpha. |
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Endogenous PML protein : biochemical analysis and study by cellular biology. |
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Etude de la persistance virale chez les Spumarétrovirus : analyse moléculaire d'une lignée chroniquement infectée et mise en évidence de délétions spécifiques dans les LTRs |
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Exploration of PLM/RARA (Promyelocytic Leukemia/Retinoic Acid Receptor Alpha) fonction in hematopoitic progenitor cells. |
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From an old remedy to a magic bullet: molecular mechanisms underlying the therapeutic effects of arsenic in fighting leukemia |
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Hematopoietic stem cells burn fat to prevent exhaustion |
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High frequency of TP53 mutation in BRCA1 and sporadic basal-like carcinomas but not in BRCA1 luminal breast tumors |
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Human T-cell lymphotropic virus type I-infected cells extravasate through the endothelial barrier by a local angiogenesis-like mechanism |
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Identification des mécanismes du facteur de transcription NFAT5 impliqués dans la migration des carcinomes mammaires |
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Impact of PML/RARA on myeloid maturation in vivo : a transcriptome, methylome and proliferation study |
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Implication de la voie Hedgehog dans la mastocytose : apport de l'étude génétique de formes rares de mastocytoses à début pédiatrique |
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Influence des isoformes de Sumo sur le trafic de la protéine PML et la dynamique des corps nucléaires |
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INTERACTION BETWEEN THE HUMAN FOAMY VIRUS (HFV) AND THE HOST CELL: ACTIVATION OF HLA CLASS ONE GENE EXPRESSION BY HFV. ASSOCIATION OF GAG POLYPEPTIDES OF HFV WITH ACTIN MICROFILAMENTS. |
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Interferon controls SUMO availability via the Lin28 and let-7 axis to impede virus replication |
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INTERRELATION ENTRE LE SPUMARETROVIRUS HUMAIN (HFV) ET LA CELLULE HOTE. ACTIVATION DES GENES HLA DE CLASSE UN PAR HFV. ASSOCIATION DES PROTEINES GAG D'HFV AVEC LES MICROFILAMENTS |
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Involvement of netrin-1/Dependence receptors (DCC and UNC5B) apoptotic control during embryonic development and tumorigenesis : apoptosis induced by dependence receptors : interface between physiology and pathology. |
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JAK2V617F myeloproliferative neoplasm eradication by a novel interferon/arsenic therapy involves PML |
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L'oncologie : de l'empirisme à la biologie intégrée |
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Un mariage réussi |
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Molecular apocrine breast cancers are aggressive estrogen receptor negative tumors overexpressing either HER2 or GCDFP15. |
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Molecular basis of NFAT1 and NFAT3 functional specificity in breast cancer. |
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Molecular mechanisms of NF-KB activation by the HTLV-I viral oncoprotein : Tax. |
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Oncologie cellulaire et moléculaire [leçon inaugurale prononcée le jeudi 8 janvier 2015] |
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Opinion: how patients have benefited from mouse models of acute promyelocytic leukaemia |
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p53 in breast cancer subtypes and new insights into response to chemotherapy |
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PML is a ROS sensor activating p53 upon oxidative stress. |
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PML IV/ARF interaction enhances p53 SUMO-1 conjugation, activation, and senescence |
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PML nuclear bodies: assembly and oxidative stress-sensitive sumoylation |
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PML nuclear bodies: regulation, function and therapeutic perspectives |
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PML-Regulated Mitochondrial Metabolism Enhances Chemosensitivity in Human Ovarian Cancers |
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Prevalence and spectrum of microsatellite alterations in nonmuscle invasive bladder cancers. |
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Promyelocytic Leukemia Protein, a Protein at the Crossroad of Oxidative Stress and Metabolism |
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Protéine PML endogène : analyse biochimique et étude en biologie celulaire |
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PROTEINES DE LA STRUCTURE R B C C ET TRANSCRIPTION |
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Rapport entre PML et les régulateurs de la voie p53 |
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Récepteurs de l'acide rétinoïque : clonage, analyse de la régulation de l'expression et implication dans l'oncogenèse |
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Relationship between PML and the regulators of the p53 pathway. |
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Retinoic acid dramatically enhances the arsenic trioxide-induced cell cycle arrest and apoptosis in retinoic acid receptor α-positive human T-cell lymphotropic virus type-I-transformed cells |
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Retinoic acid plus arsenic trioxide, the ultimate panacea for acute promyelocytic leukemia? |
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Retinoic acid signaling in acute promyelocytic leukemia : protein interactions and downstream targets |
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RING tetramerization is required for nuclear body biogenesis and PML sumoylation. |
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Rôle de RXR sur la transformation par PML-RARα |
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Rôle des modifications post-traductionnelles de PML dans la régulation et la fonction des Corps Nucléaires |
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Rôle des protéines PML et de leurs partenaires fonctionnels dans le contrôle de la sénescence cellulaire |
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RXR is an essential component of the oncogenic PML/RARA complex in vivo |
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Stability of HTLV-2 antisense protein is controlled by PML nuclear bodies in a SUMO-dependent manner. |
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Study of muscle electrotransfer with a plasmid coding an anti-inflammatory cytokine : optimisation, kinetics of production and secretion of the interleukin 10 and examples of applications on animal models of human pathologies. |
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Sulfur Derivatives of the Natural Polyarsenical Arsenicin A: Biologically Active, Organometallic Arsenic–Sulfur Cages Related to the Minerals Realgar and Uzonite |
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Targeting calcineurin activation as a therapeutic strategy for T-cell acute lymphoblastic leukemia |
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Tax ubiquitylation and sumoylation control critical cytoplasmic and nuclear steps of NF-kappaB activation |
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Ten years of molecular APL, c2001: |
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Therapeutic targeting of Tax and the NF-kB pathway in HTLV-I associated adult T cell leukemia. |
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Therapy-induced PML/RARA proteolysis and acute promyelocytic leukemia cure |
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Therapy-induced selective loss of leukemia-initiating activity in murine adult T cell leukemia |
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Titres et travaux scientifiques |
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Transcription and methylation analyses of preleukemic promyelocytes indicate a dual role for PML/RARA in leukemia initiation. |
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Uncoupling RARA transcriptional activation and degradation clarifies the bases for APL response to therapies |
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Yolk sac-derived Pdcd11-positive cells modulate zebrafish microglia differentiation through the NF-κB-Tgfβ1 pathway |
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