Edward L. LeCluyse researcher
LeCluyse, Edward
VIAF ID: 296778804 (Personal)
Permalink: http://viaf.org/viaf/296778804
Preferred Forms
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100 0 _ ‡a Edward L. LeCluyse ‡c researcher
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100 1 _ ‡a LeCluyse, Edward
4xx's: Alternate Name Forms (3)
Works
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Anti-influenza prodrug oseltamivir is activated by carboxylesterase human carboxylesterase 1, and the activation is inhibited by antiplatelet agent clopidogrel. |
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Antiplatelet agents aspirin and clopidogrel are hydrolyzed by distinct carboxylesterases, and clopidogrel is transesterificated in the presence of ethyl alcohol |
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Application of cDNA microarray to the study of arsenic-induced liver diseases in the population of Guizhou, China |
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Avasimibe induces CYP3A4 and multiple drug resistance protein 1 gene expression through activation of the pregnane X receptor |
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Cloning, tissue expression, and regulation of beagle dog CYP4A genes |
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Comparative effects of thiazolidinediones on in vitro P450 enzyme induction and inhibition |
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Comparative toxicity of trivalent and pentavalent inorganic and methylated arsenicals in rat and human cells |
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Concurrent induction and mechanism-based inactivation of CYP3A4 by an L-valinamide derivative |
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CYP3A4 induction by drugs: correlation between a pregnane X receptor reporter gene assay and CYP3A4 expression in human hepatocytes |
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Dodecylphosphocholine-mediated enhancement of paracellular permeability and cytotoxicity in Caco-2 cell monolayers. |
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Early identification of clinically relevant drug interactions with the human bile salt export pump (BSEP/ABCB11). |
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The effect of cyclophosphamide with and without dexamethasone on cytochrome P450 3A4 and 2B6 in human hepatocytes |
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Effects of avasimibe on cytochrome P450 2C9 expression in vitro and in vivo |
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Encyclopedia of drug metabolism and interactions. |
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Enhanced bioavailability of cefoxitin using palmitoylcarnitine. II. Use of directly compressed tablet formulations in the rat and dog |
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Evaluation of the effect of culture configuration on morphology, survival time, antioxidant status and metabolic capacities of cultured rat hepatocytes |
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Hemodynamic flow improves rat hepatocyte morphology, function, and metabolic activity in vitro |
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Hepatic stem cells and hepatoblasts: identification, isolation, and ex vivo maintenance. |
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Human and rat primary hepatocyte CYP1A1 and 1A2 induction with 2,3,7,8-tetrachlorodibenzo-p-dioxin, 2,3,7,8-tetrachlorodibenzofuran, and 2,3,4,7,8-pentachlorodibenzofuran. |
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Human CYP2C8 is transcriptionally regulated by the nuclear receptors constitutive androstane receptor, pregnane X receptor, glucocorticoid receptor, and hepatic nuclear factor 4alpha |
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Human PXR forms a tryptophan zipper-mediated homodimer |
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The human sulfotransferase SULT1A1 gene is regulated in a synergistic manner by Sp1 and GA binding protein |
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Incorporating human dosimetry and exposure into high-throughput in vitro toxicity screening. |
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Interindividual variation in the metabolism of arsenic in cultured primary human hepatocytes |
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Knockout of the aryl hydrocarbon receptor results in distinct hepatic and renal phenotypes in rats and mice. |
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Kupffer cell-mediated IL-2 suppression of CYP3A activity in human hepatocytes |
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Long-term stability of primary rat hepatocytes in micropatterned cocultures |
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A map of the PPARα transcription regulatory network for primary human hepatocytes. |
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Organotypic liver culture models: meeting current challenges in toxicity testing |
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P-glycoprotein expression, localization, and function in sandwich-cultured primary rat and human hepatocytes: relevance to the hepatobiliary disposition of a model opioid peptide. |
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Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME. |
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Regeneration and maintenance of bile canalicular networks in collagen-sandwiched hepatocytes. |
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Regulation of cell morphology and cytochrome P450 expression in human hepatocytes by extracellular matrix and cell-cell interactions |
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Regulation of CYP2B6 in primary human hepatocytes by prototypical inducers |
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Relationship between drug absorption enhancing activity and membrane perturbing effects of acylcarnitines |
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Relative activation of human pregnane X receptor versus constitutive androstane receptor defines distinct classes of CYP2B6 and CYP3A4 inducers |
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Role of orphan nuclear receptors in the regulation of drug-metabolising enzymes. |
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Selenium compounds modulate the activity of recombinant rat AsIII-methyltransferase and the methylation of arsenite by rat and human hepatocytes. |
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Temporal kinetics and concentration-response relationships for induction of CYP1A, CYP2B, and CYP3A in primary cultures of beagle dog hepatocytes. |
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Xenobiotic-metabolizing enzyme and transporter gene expression in primary cultures of human hepatocytes modulated by ToxCast chemicals |
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