[Ageing, genetics and the somatotropic axis] |
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The Alzheimer's disease transcriptome mimics the neuroprotective signature of IGF-1 receptor-deficient neurons. |
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Blocking IGF Signaling in Adult Neurons Alleviates Alzheimer's Disease Pathology through Amyloid-β Clearance. |
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Body surface area as a parameter of age decline. |
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Brain IGF-1 receptors control mammalian growth and lifespan through a neuroendocrine mechanism |
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CaMKIIα Expression Defines Two Functionally Distinct Populations of Granule Cells Involved in Different Types of Odor Behavior. |
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Components of the hematopoietic compartments in tumor stroma and tumor-bearing mice |
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Cre-mediated germline mosaicism: a method allowing rapid generation of several alleles of a target gene. |
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Cre-mediated recombination in the skin melanocyte lineage. |
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Decelerated growth and longevity in men. |
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Deleting IGF-1 receptor from forebrain neurons confers neuroprotection during stroke and upregulates endocrine somatotropin. |
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Disrupting IGF Signaling in Adult Mice Conditions Leanness, Resilient Energy Metabolism, and High Growth Hormone Pulses. |
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Experimental IGF-I Receptor Deficiency Generates a Sexually Dimorphic Pattern of Organ-Specific Growth Deficits in Mice, Affecting Fat Tissue in Particular |
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Exploring endocrine GH pattern in mice using rank plot analysis and random blood samples. |
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Expression of dominant-negative thyroid hormone receptor alpha1 in Leydig and Sertoli cells demonstrates no additional defect compared with expression in Sertoli cells only |
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A French academic network for sharing transgenic materials and knowledge |
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Genotyping of Cre-lox mice and detection of tissue-specific recombination by multiplex PCR |
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The GH/IGF-I axis and longevity. |
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Hepatocyte proliferation during liver regeneration is impaired in mice with liver-specific IGF-1R knockout |
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High-level IGF1R expression is required for leukemia-initiating cell activity in T-ALL and is supported by Notch signaling |
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Hypothalamic neurogenesis persists in the aging brain and is controlled by energy-sensing IGF-I pathway |
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IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice |
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[IGF-1 receptors in the brain control longevity in mice] |
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IGF-1R Reduction Triggers Neuroprotective Signaling Pathways in Spinal Muscular Atrophy Mice. |
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IGF-IR determines the fates of BCR/ABL leukemia |
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IGF signaling contributes to malignant transformation of hematopoietic progenitors by the MLL-AF9 oncoprotein. |
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IGF type 1 receptor: a cell cycle progression factor that regulates aging. |
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IGF type 1 receptor ligand binding characteristics are altered in a subgroup of children with intrauterine growth retardation |
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Igf1r signalling acts on the anagen-to-catagen transition in the hair cycle. |
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Impact de la sénescence dans la régénération musculaire. |
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Impact d'une restriction calorique modérée ou d'un mimétique potentiel, le resvératrol, sur les marqueurs du vieillissement et sur la longévité chez un primate non-humain |
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Impact of a chronic calorie restriction or a potential mimetic, the resveratrol, on the evolution of biomarkers of aging and on longevity in a primate (Microcebus murinus). |
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Inactivation de la voie IGF : impact sur la maladie d'Alzheimer et la longévité chez la souris |
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Inactivation of the IGF-I receptor gene in primary Sertoli cells highlights the autocrine effects of IGF-I. |
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Inactivation of the way IGF : impact on the Alzheimer's disease and the longevity to the mouse. |
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Insulin-like growth factor 1 receptor regulates hypothermia during calorie restriction |
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Insulin receptors in beta-cells are critical for islet compensatory growth response to insulin resistance |
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The intestinal epithelial insulin-like growth factor-1 receptor links glucagon-like peptide-2 action to gut barrier function. |
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Knockout of insulin-like growth factor-1 receptor impairs distal lung morphogenesis |
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Longevity gene IGF-1 and adult neurogenesis : regulation of lifelong neuronal replacement, olfactory function and metabolism |
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Manipulating cell fate to improve age dependent-tissue regeneration. |
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Manipulation du destin cellulaire pour améliorer la régénération tissulaire au cours du vieillissement |
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[Objective assessment of biological aging in the human: results] |
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Proinflammatory actions of visfatin/nicotinamide phosphoribosyltransferase (Nampt) involve regulation of insulin signaling pathway and Nampt enzymatic activity. |
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Quantitation of tropoelastin mRNA and assessment of alternative splicing in human skin fibroblasts by reverse transcriptase-polymerase chain reaction |
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Reduced IGF-1 signaling delays age-associated proteotoxicity in mice |
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Regulatory T cells delay disease progression in Alzheimer-like pathology. |
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Rôle de l'IGF -1R cérébral dans le vieillissement et la neuroprotection |
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Rôle des dommages à l'ADN dans la dégénérescence des cellules de la cochlée et criblage des molécules thérapeutiques |
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Role of brain IGF-1R ( type 1 insulin-like growth factor receptor) in aging and neuroprotection. |
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Role of DNA damage in cochlear cell degeneration : from molecular pathways to therapies. |
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The role of insulin-like signalling in the regulation of ageing. |
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The role of neuron morphology in the regulation of molecular fluxes in the ECS of the cerebral cortex : A potential mechanism of IGF-dependant neuroprotection. |
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Rôles pléiotropiques du récepteur IGF dans la régulation du vieillissement |
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Selective expression of insulin-like growth factor II in the songbird brain. |
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Signalisation IGF et maladie d'Alzheimer : mécanismes cellulaires et moléculaires |
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Suppression of IGF-I signals in neural stem cells enhances neurogenesis and olfactory function during aging. |
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A Targeted Partial Invalidation of the Insulin-Like Growth Factor I Receptor Gene in Mice Causes a Postnatal Growth Deficit |
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Thyrocyte-specific deletion of insulin and IGF-1 receptors induces papillary thyroid carcinoma-like lesions through EGFR pathway activation |
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Total insulin and IGF-I resistance in pancreatic beta cells causes overt diabetes |
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Tropoelastin gene expression in the developing vascular system of the chicken: an in situ hybridization study |
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[Two strains of genetically hypertensive rats, LH and SRH, have distinct profiles of postnatal expression of tropoelastin and type III collagen in the aortic wall] |
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