Benoit Deprez researcher
Déprez, Benoît
VIAF ID: 211270943 (Personal)
Permalink: http://viaf.org/viaf/211270943
Preferred Forms
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100 0 _ ‡a Benoit Deprez ‡c researcher
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100 1 _ ‡a Déprez, Benoît
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100 1 _ ‡a Déprez, Benoît
4xx's: Alternate Name Forms (1)
Works
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ADAM30 Downregulates APP-Linked Defects Through Cathepsin D Activation in Alzheimer's Disease |
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Alkylsquarates as key intermediates for the rapid preparation of original drug-inspired compounds |
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Association of proteasome inhibition and a new compound in the treatment of multiple myeloma. |
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Bibliothèques combinatoires : préparations et utilisations en pharmacochimie et en immunologie |
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The Bile Acid Chenodeoxycholic Acid Increases Human Brown Adipose Tissue Activity. |
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Caractérisation du mécanisme d'action de petites molécules dans le cancer |
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Catalytic site inhibition of insulin-degrading enzyme by a small molecule induces glucose intolerance in mice |
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Characterization of monoclonal antibodies by a fast and easy liquid chromatography-mass spectrometry time-of-flight analysis on culture supernatant |
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Characterization of the mechanism of action of small molecules in cancer. |
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ChemInform Abstract: Efficient Propylphosphonic Anhydride (®T3P) Mediated Synthesis of Benzothiazoles, Benzoxazoles and Benzimidazoles |
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Combinaison de l'inhibition du protéasome et d'un nouveau composé dans le traitement du myélome multiple |
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Combinatorial libraries : preparation and use in pharmacochemistry and immunology. |
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Comparative efficiency of simple lipopeptide constructs for in vivo induction of virus-specific CTL. |
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Conception d'une stratégie de découverte de composés antiviraux contre les coronavirus : du criblage à l'optimisation d'inhibiteurs de la protéase 3CL du SARS-CoV-2 |
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Controlling Plasma Stability of Hydroxamic Acids: A MedChem Toolbox. |
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Découverte de composés à activité antiplasmodiale : nouvelle approche |
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Design of a strategy for the discovery of antiviral compounds against coronaviruses : from screening to optimization of SARS-CoV-2 3CL protease inhibitors. |
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Design, synthesis and pharmacological evaluation of protein-protein interactions inhibitors involved in cancer. |
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Designing focused chemical libraries enriched in protein-protein interaction inhibitors using machine-learning methods |
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Development of pharmacological tools to understand the role of Insulin Degrading Enzyme (IDE) in the regulation of proteotoxic stress. |
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Discovery and process development of a novel TACE inhibitor for the topical treatment of psoriasis. |
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Drug-to-genome-to-drug, step 2: reversing selectivity in a series of antiplasmodial compounds |
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Dynamics of the uses of plastic containers and study of the transfer of bisphenols and phthalates to food matrices. |
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Dynamique des usages des récipients plastiques et étude du transfert des bisphénols et phtalates vers les matrices alimentaires |
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Efficient analoging around ethionamide to explore thioamides bioactivation pathways triggered by boosters in Mycobacterium tuberculosis |
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Efficient, two-step synthesis of N-substituted nortropinone derivatives |
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Exploring drug target flexibility using in situ click chemistry: application to a mycobacterial transcriptional regulator |
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Facts, figures and trends in lead generation |
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Friedländer synthesis of polysubstituted quinolines and naphthyridines promoted by propylphosphonic anhydride (T3P®) under mild conditions |
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From hit to lead. Analyzing structure-profile relationships. |
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From hit to lead. Combining two complementary methods for focused library design. Application to mu opiate ligands. |
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Genome-wide, high-content siRNA screening identifies the Alzheimer's genetic risk factor FERMT2 as a major modulator of APP metabolism |
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Hydroxamates: relationships between structure and plasma stability |
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Identification of Small Inhibitory Molecules Targeting the Bfl-1 Anti-Apoptotic Protein That Alleviates Resistance to ABT-737. |
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In silico-in vitro screening of protein-protein interactions: towards the next generation of therapeutics |
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In vivo efficacy of microbiota-sensitive coatings for colon targeting: a promising tool for IBD therapy |
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Inhibition of aggrecanases as a therapeutic strategy in osteoarthritis. |
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Inhibition of the glucose transporter SGLT2 with dapagliflozin in pancreatic alpha cells triggers glucagon secretion. |
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Kinetic target-guided synthesis in drug discovery and chemical biology: a comprehensive facts and figures survey |
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Kinetic Target-Guided Synthesis: Reaching the Age of Maturity |
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Lewis acid-induced reaction of homophthalic anhydride with imines: a convenient synthesis of trans-isoquinolonic acids |
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A library of novel hydroxamic acids targeting the metallo-protease family: design, parallel synthesis and screening |
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Ligand efficiency driven design of new inhibitors of Mycobacterium tuberculosis transcriptional repressor EthR using fragment growing, merging, and linking approaches |
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Long-lasting anti-viral cytotoxic T lymphocytes induced in vivo with chimeric-multirestricted lipopeptides |
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MALDI imaging techniques dedicated to drug-distribution studies |
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Microsphiltration screening assay to discover compounds decreasing the deformability of plasmodium falciparum gametocytes, thereby interrupting the transmission of malaria. |
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Microwave-assisted synthesis of functionalized spirohydantoins as 3-D privileged fragments for scouting the chemical space |
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Natural compounds: leads or ideas? Bioinspired molecules for drug discovery |
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New methodologies for peptides and polypeptides synthesis using the O-N acyl shift. |
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New non-hydroxamic ADAMTS-5 inhibitors based on the 1,2,4-triazole-3-thiol scaffold. |
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Novel non-carboxylic acid retinoids: 1,2,4-oxadiazol-5-one derivatives |
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Novel selective inhibitors of neutral endopeptidase: discovery by screening and hit-to-lead optimisation |
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Novel selective inhibitors of the zinc plasmodial aminopeptidase PfA-M1 as potential antimalarial agents. |
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PDE5 inhibitors: An original access to novel potent arylated analogues of tadalafil |
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Pimelautide or trimexautide as built-in adjuvants associated with an HIV-1-derived peptide: synthesis and in vivo induction of antibody and virus-specific cytotoxic T-lymphocyte-mediated response. |
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Preface [Hot topic: Hit-to-Lead: Driving Forces for the Medicinal Chemist (Guest Editor: Benoit Deprez and Rebecca Deprez-Poulain)] |
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Racemic and diastereoselective construction of indole alkaloids under solvent- and catalyst-free microwave-assisted Pictet–Spengler condensation |
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La réaction de transfert O-N acylique : nouvelles applications pour la synthèse de peptides et de polypeptides |
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Rescue of nonsense mutations by amlexanox in human cells |
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Reversion of antibiotic resistance in Mycobacterium tuberculosis by spiroisoxazoline SMARt-420. |
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Setting Up a Bioluminescence Resonance Energy Transfer High throughput Screening Assay to Search for Protein/Protein Interaction Inhibitors in Mammalian Cells |
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A simple reaction to produce small structurally complex and diverse molecules |
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Squaric acid is a suitable building-block in 4C-Ugi reaction: access to original bivalent compounds |
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Stereoselective synthesis of enantiopure N-protected-3-arylpiperazines from keto-esters |
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Structural activation of the transcriptional repressor EthR from Mycobacterium tuberculosis by single amino acid change mimicking natural and synthetic ligands |
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Structural and docking studies of potent ethionamide boosters |
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Structure-activity relationships and blood distribution of antiplasmodial aminopeptidase-1 inhibitors |
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Structure-activity relationships of imidazole-derived 2-[N-carbamoylmethyl-alkylamino]acetic acids, dual binders of human insulin-degrading enzyme. |
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Synthèse d'inhibiteurs potentiels non phosphorylés de la désoxyxylulose phosphate réductoisomérase et étude de la voie de biosynthèse des unités isopréniques chez Acanthamoeba polyphaga |
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Synthesis and structural studies of a novel scaffold for drug discovery: a 4,5-dihydro-3H-spiro[1,5-benzoxazepine-2,4′-piperidine] |
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Synthesis of five- and six-membered lactams via solvent-free microwave Ugi reaction |
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Synthesis of functionalized 2-isoxazolines as three-dimensional fragments for fragment-based drug discovery |
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Synthesis of N-(iodophenyl)-amides via an unprecedented Ullmann–Finkelstein tandem reaction |
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Synthetic EthR inhibitors boost antituberculous activity of ethionamide |
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Topical Intestinal Aminoimidazole Agonists of G-Protein-Coupled Bile Acid Receptor 1 Promote Glucagon Like Peptide-1 Secretion and Improve Glucose Tolerance. |
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Tuberculosis: the drug development pipeline at a glance |
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UFU |
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UFU (‘Ullmann–Finkelstein–Ullmann’): a new multicomponent reaction |
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Ugi reaction for the synthesis of 4-aminopiperidine-4-carboxylic acid derivatives. Application to the synthesis of carfentanil and remifentanil |
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Unconventional surface plasmon resonance signals reveal quantitative inhibition of transcriptional repressor EthR by synthetic ligands |
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L’Unfolded Protein response dans le cancer : de nouvelles cibles thérapeutiques ? |
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Water-based conditions for the microscale parallel synthesis of bicyclic lactams |
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