The antimalarial activities of methylene blue and the 1,4-naphthoquinone 3-[4-(trifluoromethyl)benzyl]-menadione are not due to inhibition of the mitochondrial electron transport chain |
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Antimalarial NADPH-Consuming Redox-Cyclers As Superior Glucose-6-Phosphate Dehydrogenase Deficiency Copycats |
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Antiparasitic benzyl-menadiones : a study of their mode of action and of their efficacy to block transmission of the malaria parasite to the Anopheles gambiae mosquito vector. |
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Antiplasmodial activity and cytotoxicity of bis-, tris-, and tetraquinolines with linear or cyclic amino linkers |
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Antitrypanosomal activities and cytotoxicity of 5-nitro-2-furancarbohydrazides. |
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The aza-analogues of 1,4-naphthoquinones are potent substrates and inhibitors of plasmodial thioredoxin and glutathione reductases and of human erythrocyte glutathione reductase |
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Bromination studies of the 2,3-dimethylnaphthazarin core allowing easy access to naphthazarin derivatives |
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Comparison of the inhibition of human and Trypanosoma cruzi prolyl endopeptidases |
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CONCEPTION ET SYNTHESE D'INHIBITEURS DE LA TRYPANOTHION REDUCTASE DE TRYPANOSOMA CRUZI DANS LE TRAITEMENT DE LA MALADIE DE CHAGAS (DOCTORAT : CHIMIE ORGANIQUE A VISEE THERAPEUTIQUE) |
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The conserved redox-sensitive cysteine residue of the DNA-binding region in the c-Rel protein is involved in the regulation of the phosphorylation of the protein |
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Development of chemical tools and selective plasmodione activity-based probes to identify the targets of this new antimalarial agent. |
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Développement d'outils chimiques et de sondes sélectives basées sur l'activité de la plasmodione pour identifier les cibles de ce nouvel agent antipaludique |
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Dynamique de la flexibilité des activités des protéines prényltransférases. |
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Étude d'aminoarylalcools énantiomériquement purs à visée antipaludique |
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ETUDE D'UNE COLLECTION PRIVEE DE MORTIERS |
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Evidence for the co-existence of glutathione reductase and trypanothione reductase in the non-trypanosomatid Euglenozoa: Euglena gracilis Z |
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Exploring the trifluoromenadione core as a template to design antimalarial redox-active agents interacting with glutathione reductase. |
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Flavones substituées : une nouvelle classe de composés pour le traitement du paludisme : optimisation vers un candidat médicament |
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A fluoro analogue of the menadione derivative 6-[2'-(3'-methyl)-1',4'-naphthoquinolyl]hexanoic acid is a suicide substrate of glutathione reductase. Crystal structure of the alkylated human enzyme |
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A General Approach to the Synthesis of Polyamine Linked-Monoindolylmaleimides, a New Series of Trypanothione Reductase Inhibitors |
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Glutathione-dependent activities of Trypanosoma cruzi p52 makes it a new member of the thiol:disulphide oxidoreductase family |
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Le hairy root : source de métabolites secondaires : la cucumopine : les alcaloi͏̈des indoliques |
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A high susceptibility to redox imbalance of the transmissible stages of Plasmodium falciparum revealed with a luciferase-based mature gametocyte assay |
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Implications of redox mechanisms in the mode of action of antimalarials and resistance to artemisinin. |
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An improved synthesis of 18-norandrost-4-ene-3,17-dione |
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In Silico Mining for Antimalarial Structure-Activity Knowledge and Discovery of Novel Antimalarial Curcuminoids. |
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Interactions of the antimalarial drug methylene blue with methemoglobin and heme targets in Plasmodium falciparum: a physico-biochemical study |
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Investigating the mode of action of the redox-active antimalarial drug plasmodione using the yeast model |
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Iridoids of Guyanese Species of Stigmaphyllon |
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Iron(iii) coordination properties of ladanein, a flavone lead with a broad-spectrum antiviral activity |
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Irreversible inactivation of trypanothione reductase by unsaturated Mannich bases: a divinyl ketone as key intermediate |
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Mechanism-based inactivation of thioredoxin reductase from Plasmodium falciparum by Mannich bases. Implication for cytotoxicity |
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Mechanistic studies on a novel, highly potent gold-phosphole inhibitor of human glutathione reductase |
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A Mild and Versatile Friedel-Crafts Methodology for the Diversity-Oriented Synthesis of Redox-Active 3-Benzoylmenadiones with Tunable Redox Potentials |
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The mineralocorticoid activity of progesterone derivatives depends on the nature of the C18 substituent |
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New spermine and spermidine derivatives as potent inhibitors of Trypanosoma cruzi Trypanothione Reductase |
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Nouvelles méthodologies de synthèse de 3-benz(o)ylménadiones et propriétés rédox à l'origine de leur(s) mode(s) d'action antipaludique |
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Nouvelles stratégies d'amplification moléculaire d'un signal basées sur l'activation de dérivés pro-quinoniques : de l'activation d'un catalyseur biomoléculaire au déclenchement d'une réaction auto-catalytique |
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Outils moléculaires pour le développement de médicaments antipaludiques : synthèse d’analogues de plasmodione et de 13C18-plasmodione pour des recherches en métabolomique. |
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Photoaffinity labelling of the human mineralocorticoid receptor with steroids having a reactive group at position 3, 18 or 21. |
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Physicochemical Properties Govern the Activity of Potent Antiviral Flavones |
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A prodrug form of a Plasmodium falciparum glutathione reductase inhibitor conjugated with a 4-anilinoquinoline. |
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Propriétés antiparasitaires des benzyl-ménadiones : étude de leur mécanisme d'action et de leur potentiel à bloquer la transmission des parasites du paludisme au moustique vecteur Anopheles gambiae |
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QSAR modeling and chemical space analysis of antimalarial compounds |
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Réactions multicomposants de lawsone : vers des composés antiparasitaires et diversement actifs sur le plan biologique |
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Recherche des molécules antiparasitaires à l'interface de l'ethnopharmacologie, des sciences analytiques et de la biologie |
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Redox-active 3-benzyl-menadiones as new antimalarial agents : studies on structure-activity relationships, antiparasitic potency and mechanism of action |
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A Redox-Active Fluorescent pH Indicator for Detecting Plasmodium falciparum Strains with Reduced Responsiveness to Quinoline Antimalarial Drugs |
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The Redox Cycler Plasmodione Is a Fast-Acting Antimalarial Lead Compound with Pronounced Activity against Sexual and Early Asexual Blood-Stage Parasites |
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Redox Polypharmacology as an Emerging Strategy to Combat Malarial Parasites |
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Repurposing Auranofin and Evaluation of a New Gold(I) Compound for the Search of Treatment of Human and Cattle Parasitic Diseases: From Protozoa to Helminth Infections |
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Screening of Plasmodium falciparum iron superoxide dismutase inhibitors and accuracy of the SOD-assays |
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Selenium Status in Elderly People: Longevity and Age-Related Diseases |
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Specific inhibitors of Plasmodium falciparum thioredoxin reductase as potential antimalarial agents. |
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Structural, enzymatic characterization and research of target molecules of the poplar glutathione transferase Phi. |
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Structure-activity relationships in 2-aminodiphenylsulfides against trypanothione reductase from Trypanosoma cruzi |
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Study of in vitro susceptibility to benznidazole and to a novel anti chagas agent, JN034, of Trypanosoma cruzi strains belonging to different Discrete Typing Units : meta-analysis and preliminary anti chagas profile. |
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Substituted flavones : a new class of compounds to treat malaria : hit to lead optimization. |
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Synthèse et évaluation biologique de dérivés polyamines en tant qu’agents antikinétoplastidés. |
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Synthèse et évaluation de l'activité anti-Leishmania d'anthranoïdes issus du genre Psorospermum (Hypericaceae) utilisé en médecine traditionnelle camerounaise |
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Synthèse et évaluation de thiopyranones et de leur S-oxydes associés comme prodrogues de diarylidèneacétones à activité antiparasitaire. |
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Synthèse et mécanisme d'action de 1,4-naphtoquinones comme substrats subversifs de disulfure réductases affectant l'équilibre rédox des schistosomes et des parasites du paludisme. |
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Synthesis and evaluation of 1,4-naphthoquinone ether derivatives as SmTGR inhibitors and new anti-schistosomal drugs |
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Synthesis and physico-chemical study of a novel flavone antiviral lead |
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Synthesis of 5,5'-dithiobis(2-nitrobenzamides) as alternative substrates for trypanothione reductase and thioredoxin reductase: a microtiter colorimetric assay for inhibitor screening. |
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Synthesis of plasmodione metabolites and 13C-enriched plasmodione as chemical tools for drug metabolism investigation. |
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Synthesis of polyamine derivatives for the preparation of affinity chromatography columns for the search of new Trypanosoma cruzi targets |
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Thioredoxin glutathione reductase from Schistosoma mansoni: an essential parasite enzyme and a key drug target |
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Total synthesis of polysubstituted antiparasitic (aza)naphtoquinones. |
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Towards to total synthesis of mucangimycin and its more stable and simplified analogs. |
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Trypanosoma cruzi prolyl oligopeptidase Tc80 is involved in nonphagocytic mammalian cell invasion by trypomastigotes. |
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Trypanothione reductase inhibition/trypanocidal activity relationships in a 1,4-bis(3-aminopropyl)piperazine series |
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Undressing of phosphine gold(I) complexes as irreversible inhibitors of human disulfide reductases |
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Unsaturated Mannich bases active against multidrug-resistant Trypanosoma brucei brucei strains |
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Vers la synthèse totale de la mycangimycine, un acide gras polyènique peroxydé, et synthèse d'analogues plus stables et simplifiés |
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