Development of dimeric modulators for anti-apoptotic Bcl-2 proteins |
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Distinct lipid effects on tBid and Bim activation of membrane permeabilization by pro-apoptotic Bax |
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Distinct pathways mediate the sorting of tail-anchored proteins to the plastid outer envelope |
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Drugs targeting Bcl-2 family members as an emerging strategy in cancer |
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Electron microscopy of the poly-L-lysine alpha-helix |
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Endoplasmic reticulum localized Bcl-2 prevents apoptosis when redistribution of cytochrome c is a late event |
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The environment of nascent secretory and membrane proteins at the endoplasmic reticulum membrane during translocation and integration |
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Essential versus accessory aspects of cell death: recommendations of the NCCD 2015. |
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Evidence for multiple mechanisms for membrane binding and integration via carboxyl-terminal insertion sequences |
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Evidence Implicating Immunological Host Effects in the Efficacy of Metronomic Low-Dose Chemotherapy |
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Evidence that the middle T antigen of polyomavirus interacts with the membrane skeleton |
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Examining protein translocation in cell-free systems and microinjected Xenopus oocytes |
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Examining the molecular mechanism of bcl-2 family proteins at membranes by fluorescence spectroscopy |
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FimH can directly activate human and murine natural killer cells via TLR4 |
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FtsY binds to the Escherichia coli inner membrane via interactions with phosphatidylethanolamine and membrane proteins |
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Genome-wide analysis of Homo sapiens, Arabidopsis thaliana, and Saccharomyces cerevisiae reveals novel attributes of tail-anchored membrane proteins |
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GIMAP5 regulates mitochondrial integrity from a distinct subcellular compartment |
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Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes. |
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High-content screening identifies kinase inhibitors that overcome venetoclax resistance in activated CLL cells |
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High dose electron microscopy of macromolecules. Date. Canadian. |
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High-speed multifocal array scanning using refractive window tilting |
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Hydrophobic-domain-dependent protein-protein interactions mediate the localization of GPAT enzymes to ER subdomains |
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Image-Based Analysis of Protein Stability |
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Improving drug discovery using image-based multiparametric analysis of the epigenetic landscape |
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Inhibition of p53 transcriptional activity by Bcl-2 requires its membrane-anchoring domain |
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Interaction of the full-length Bax protein with biomimetic mitochondrial liposomes: a small-angle neutron scattering and fluorescence study. |
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Interaction with a membrane surface triggers a reversible conformational change in Bax normally associated with induction of apoptosis |
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Interactions of pro-apoptotic BH3 proteins with anti-apoptotic Bcl-2 family proteins measured in live MCF-7 cells using FLIM FRET. |
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Interstitial cells of Cajal generate a rhythmic pacemaker current |
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Janus and PI3-kinases mediate glucocorticoid resistance in activated chronic leukemia cells. |
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Lipid Droplet-Associated Proteins (LDAPs) Are Required for the Dynamic Regulation of Neutral Lipid Compartmentation in Plant Cells. |
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Membrane binding by tBid initiates an ordered series of events culminating in membrane permeabilization by Bax |
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Membrane-bound fatty acid desaturases are inserted co-translationally into the ER and contain different ER retrieval motifs at their carboxy termini |
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The mevalonate pathway is an actionable vulnerability of t(4;14)-positive multiple myeloma |
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MiRNA-106a and prostate cancer radioresistance: a novel role for LITAF in ATM regulation. |
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Mitochondrial hexokinase II (HKII) and phosphoprotein enriched in astrocytes (PEA15) form a molecular switch governing cellular fate depending on the metabolic state |
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Mitochondrio-nuclear translocation of AIF in apoptosis and necrosis |
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Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018. |
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Molecular Pathways: Leveraging the BCL-2 Interactome to Kill Cancer Cells--Mitochondrial Outer Membrane Permeabilization and Beyond |
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Multiple partners can kiss-and-run: Bax transfers between multiple membranes and permeabilizes those primed by tBid |
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Multiple post-translational modifications regulate E-cadherin transport during apoptosis |
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The MYC oncoprotein directly interacts with its chromatin cofactor PNUTS to recruit PP1 phosphatase |
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Negatively charged residues in the IgM stop-transfer effector sequence regulate transmembrane polypeptide integration |
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Neuronal cell life, death, and axonal degeneration as regulated by the BCL-2 family proteins |
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New insights into the targeting of a subset of tail-anchored proteins to the outer mitochondrial membrane |
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Optimizing the acquisition and analysis of confocal images for quantitative single-mobile-particle detection. |
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Peak emission wavelength and fluorescence lifetime are coupled in far-red, GFP-like fluorescent proteins |
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Phosphorylation switches Bax from promoting to inhibiting apoptosis thereby increasing drug resistance. |
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Photodamage to multiple Bcl-xL isoforms by photodynamic therapy with the phthalocyanine photosensitizer Pc 4. |
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Pores of no return |
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The proapoptotic protein tBid forms both superficially bound and membrane-inserted oligomers. |
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Problems with Co-Funding in Canada |
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Protein origami for beginners |
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Rapid 3D phenotypic analysis of neurons and organoids using data-driven cell segmentation-free machine learning |
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Regulating cell death at, on, and in membranes. |
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Regulation of acidification and apoptosis by SHP-1 and Bcl-2 |
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Regulation of Ca2+-induced permeability transition by Bcl-2 is antagonized by Drpl and hFis1 |
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The relative biological effectiveness of low-dose mammography quality X rays in the human breast MCF-10A cell line |
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Removing bias against membrane proteins in interaction networks |
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The role of the N region in signal sequence and signal-anchor function |
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Saccharomyces cerevisiae peroxisomal thiolase is imported as a dimer. |
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Sequences beyond the cleavage site influence signal peptide function. |
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Shedding light on apoptosis at subcellular membranes |
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The signal recognition particle receptor alpha subunit assembles co-translationally on the endoplasmic reticulum membrane during an mRNA-encoded translation pause in vitro. |
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A single nucleotide is a sufficient 5' untranslated region for translation in an eukaryotic in vitro system. |
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Site-directed mutagenesis by inverse PCR. |
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A Small-Molecule Inhibitor of Bax and Bak Oligomerization Prevents Genotoxic Cell Death and Promotes Neuroprotection. |
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Small molecules reveal an alternative mechanism of Bax activation. |
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Stability and function of the Sec61 translocation complex depends on the Sss1p tail-anchor sequence |
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Still embedded together binding to membranes regulates Bcl-2 protein interactions. |
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Streak camera crosstalk reduction using a multiple delay optical fiber bundle |
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A structure for the signal sequence binding protein SRP54: 3D reconstruction from STEM images of single molecules |
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The structure of Escherichia coli signal recognition particle revealed by scanning transmission electron microscopy. |
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Suppression of IP3-mediated calcium release and apoptosis by Bcl-2 involves the participation of protein phosphatase 1 |
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Switching the model: a concerted mechanism for GTPases in protein targeting |
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Tamoxifen and ICI 182,780 increase Bcl-2 levels and inhibit growth of breast carcinoma cells by modulating PI3K/AKT, ERK and IGF-1R pathways independent of ERalpha |
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Targeting of passenger protein domains to multiple intracellular membranes |
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tBid elicits a conformational alteration in membrane-bound Bcl-2 such that it inhibits Bax pore formation |
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tBid undergoes multiple conformational changes at the membrane required for Bax activation |
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TCTP contains a BH3-like domain, which instead of inhibiting, activates Bcl-xL |
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There is more to life and death than mitochondria: Bcl-2 proteins at the endoplasmic reticulum |
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The translocon: more than a hole in the ER membrane? |
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Transport across membranes: a question of navigation. |
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Tunable hydrogel thin films from reactive synthetic polymers as potential two-dimensional cell scaffolds |
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Unleashing Blocked Apoptosis in Cancer Cells: New MCL1 Inhibitors Find Their Groove |
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The use of FLIM-FRET for the detection of mitochondria-associated protein interactions |
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Using Förster-Resonance Energy Transfer to Measure Protein Interactions Between Bcl-2 Family Proteins on Mitochondrial Membranes |
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A Versatile Cell Death Screening Assay Using Dye-Stained Cells and Multivariate Image Analysis |
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