Preferred Forms
- 100 0 _ ‡a Channing Der
- 200 _ | ‡a Der ‡b Channing J.
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- 100 1 _ ‡a Der, Channing J
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- 100 1 0 ‡a Der, Channing J.
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- 100 1 _ ‡a Der, Channing J. (sparse)
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- 100 1 _ ‡a Der, Channing J.
- 100 1 _ ‡a Der, Channing J.
4xx's: Alternate Name Forms (3)
Works
Title | Sources |
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Aberrant overexpression of the Rgl2 Ral small GTPase-specific guanine nucleotide exchange factor promotes pancreatic cancer growth through Ral-dependent and Ral-independent mechanisms | |
Analysis of RAS protein interactions in living cells reveals a mechanism for pan-RAS depletion by membrane-targeted RAS binders | |
Application of a MYC degradation screen identifies sensitivity to CDK9 inhibitors in KRAS-mutant pancreatic cancer | |
The C. elegans Chp/Wrch Ortholog CHW-1 Contributes to LIN-18/Ryk and LIN-17/Frizzled Signaling in Cell Polarity | |
Combination of ERK and autophagy inhibition as a treatment approach for pancreatic cancer | |
Critical but distinct roles for the pleckstrin homology and cysteine-rich domains as positive modulators of Vav2 signaling and transformation | |
CRL4A-FBXW5-mediated degradation of DLC1 Rho GTPase-activating protein tumor suppressor promotes non-small cell lung cancer cell growth | |
Drugging RAS: Know the enemy | |
The enzymes | |
Evaluation of the selectivity and sensitivity of isoform- and mutation-specific RAS antibodies. | |
Genetic and functional characterization of putative Ras/Raf interaction inhibitors in C. elegans and mammalian cells | |
Geranylgeranyltransferase I inhibitors target RalB to inhibit anchorage-dependent growth and induce apoptosis and RalA to inhibit anchorage-independent growth | |
GTP-binding mutants of rab1 and rab2 are potent inhibitors of vesicular transport from the endoplasmic reticulum to the Golgi complex | |
GTPases involved in vesicular traffic | |
GTPases regulating membrane dynamics | |
Honokiol, a small molecular weight natural product, inhibits angiogenesis in vitro and tumor growth in vivo | |
Identification and characterization of rain, a novel Ras-interacting protein with a unique subcellular localization | |
Identity of HeLa Cell Determinants Acquired by Vesicular Stomatitis Virus with a Tumor Antigen | |
Inhibiting farnesylation of progerin prevents the characteristic nuclear blebbing of Hutchinson-Gilford progeria syndrome | |
Inhibitors of the Ras superfamily G-proteins. | |
Involvement of phosphatidylinositol 3-kinase, but not RalGDS, in TC21/R-Ras2-mediated transformation | |
Isoprenoid addition to Ras protein is the critical modification for its membrane association and transforming activity | |
Isoprenoid modification of rab proteins terminating in CC or CXC motifs | |
K-Ras promotes angiogenesis mediated by immortalized human pancreatic epithelial cells through mitogen-activated protein kinase signaling pathways | |
KRAS Mutant Pancreatic Cancer: No Lone Path to an Effective Treatment | |
Lack of correlation between the decreased expression of cell surface LETS protein and tumorigenicity in human cell hybrids | |
Ligand-dependent dynamics and intramolecular signaling in a PDZ domain | |
Long-Term ERK Inhibition in KRAS-Mutant Pancreatic Cancer Is Associated with MYC Degradation and Senescence-like Growth Suppression | |
Loss of transgelin in breast and colon tumors and in RIE-1 cells by Ras deregulation of gene expression through Raf-independent pathways | |
Molecular pathways: targeting RAC-p21-activated serine-threonine kinase signaling in RAS-driven cancers | |
Multiple sequence elements facilitate Chp Rho GTPase subcellular location, membrane association, and transforming activity | |
P-Rex1 is required for efficient melanoblast migration and melanoma metastasis | |
Protein prenylation: more than just glue? | |
Ras effector switching promotes divergent cell fates in C. elegans vulval patterning | |
RAS family GTPases | |
Ras history: The saga continues | |
RAS isoforms and mutations in cancer at a glance | |
The Ras superfamily at a glance | |
RAS, wanted dead or alive: Advances in targeting RAS mutant cancers | |
RasGRP4 is a novel Ras activator isolated from acute myeloid leukemia | |
Regulation of Rnd3 localization and function by protein kinase C alpha-mediated phosphorylation | |
Regulator of G-protein signaling 14 (RGS14) is a selective H-Ras effector | |
Regulators and effectors of small GTPases | |
Release of autoinhibition of ASEF by APC leads to CDC42 activation and tumor suppression | |
Rho family | |
RhoE is a pro-survival p53 target gene that inhibits ROCK I-mediated apoptosis in response to genotoxic stress | |
RhoG signals in parallel with Rac1 and Cdc42 | |
The RhoGEF TEM4 Regulates Endothelial Cell Migration by Suppressing Actomyosin Contractility | |
Rnd proteins function as RhoA antagonists by activating p190 RhoGAP | |
ROCK-generated contractility regulates breast epithelial cell differentiation in response to the physical properties of a three-dimensional collagen matrix | |
ROCK1 and ROCK2 are required for non-small cell lung cancer anchorage-independent growth and invasion | |
Role of MAP kinases in the 1,25-dihydroxyvitamin D3-induced transactivation of the rat cytochrome P450C24 (CYP24) promoter. Specific functions for ERK1/ERK2 and ERK5 | |
Role of MLK3-mediated activation of p70 S6 kinase in Rac1 transformation | |
A six-gene signature predicts survival of patients with localized pancreatic ductal adenocarcinoma | |
Small GTPases in disease | |
Specific isoprenoid modification is required for function of normal, but not oncogenic, Ras protein | |
Structural basis for the selective activation of Rho GTPases by Dbl exchange factors | |
Structure and biological effects of lipid modifications on proteins | |
Tiam1 mediates Ras activation of Rac by a PI(3)K-independent mechanism | |
Transformation by a nucleotide-activated P2Y receptor is mediated by activation of Galphai, Galphaq and Rho-dependent signaling pathways | |
A tumor-specific membrane phosphoprotein marker in human cell hybrids | |
XPLN, a guanine nucleotide exchange factor for RhoA and RhoB, but not RhoC |