Guarente, Leonard.
Leonard P. Guarente
Guarente, Leonard P.
Guarente, Leonard 1952-
גוארנטה, לאונרד
Guarente, Lenny
VIAF ID: 12633482 (Personal)
Permalink: http://viaf.org/viaf/12633482
Preferred Forms
- 200 _ | ‡a Guarente ‡b Leonard P.
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- 100 1 _ ‡a Guarente, Leonard
- 100 1 _ ‡a Guarente, Leonard
- 100 1 _ ‡a Guarente, Leonard
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- 100 1 _ ‡a Guarente, Leonard
- 100 1 _ ‡a Guarente, Leonard P.
- 100 1 _ ‡a Guarente, Leonard ‡d 1952-
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- 100 0 _ ‡a Leonard P. Guarente
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4xx's: Alternate Name Forms (18)
Works
Title | Sources |
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3-Ketoacyl thiolase delays aging of Caenorhabditis elegans and is required for lifespan extension mediated by sir-2.1. | |
Abstracts of papers presented at the 1998 meeting on genetics of aging, 1998: | |
Accelerated aging and nucleolar fragmentation in yeast sgs1 mutants | |
Ageless quest, 2002: | |
Aging and Rejuvenation: Insights from Rusty Gage, Leonard Guarente, and Amy Wagers. | |
Alternative translation initiation generates a novel isoform of insulin-degrading enzyme targeted to mitochondria | |
C. elegans SIR-2.1 interacts with 14-3-3 proteins to activate DAF-16 and extend life span | |
Cassette for the generation of sequential gene disruptions in the yeast Schizosaccharomyces pombe. | |
Cloning the gene for Werner syndrome: a disease with many symptoms of premature aging | |
Daughter cells of Saccharomyces cerevisiae from old mothers display a reduced life span | |
Deviation of innate circadian period from 24 h reduces longevity in mice. | |
Dietary restriction: standing up for sirtuins | |
Efficacy and tolerability of EH301 for amyotrophic lateral sclerosis: a randomized, double-blind, placebo-controlled human pilot study | |
Essential role of limiting telomeres in the pathogenesis of Werner syndrome | |
Extrachromosomal rDNA circles--a cause of aging in yeast | |
Genetic links between diet and lifespan: shared mechanisms from yeast to humans | |
Genetic pathways that regulate ageing in model organisms | |
Genomic instability and aging-like phenotype in the absence of mammalian SIRT6 | |
Impairment of an Endothelial NAD-HS Signaling Network Is a Reversible Cause of Vascular Aging | |
Increase in activity during calorie restriction requires Sirt1 | |
Intestinal Epithelial Sirtuin 1 Regulates Intestinal Inflammation During Aging in Mice by Altering the Intestinal Microbiota | |
Introductory review on sirtuins in biology, aging, and disease | |
Life-span extension in yeast. | |
Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation | |
Mammalian Sir2 homolog SIRT7 is an activator of RNA polymerase I transcription | |
Mammalian SIRT1 represses forkhead transcription factors | |
MEC1-dependent redistribution of the Sir3 silencing protein from telomeres to DNA double-strand breaks | |
Model organisms as a guide to mammalian aging | |
Molecular biology of aging | |
Mouse Sir2 homolog SIRT6 is a nuclear ADP-ribosyltransferase | |
mTORC1 and SIRT1 Cooperate to Foster Expansion of Gut Adult Stem Cells during Calorie Restriction. | |
Muscle-specific SIRT1 gain-of-function increases slow-twitch fibers and ameliorates pathophysiology in a mouse model of duchenne muscular dystrophy | |
Mutation in the silencing gene S/R4 can delay aging in S. cerevisiae | |
Mutations that Allow SIR2 Orthologs to Function in a NAD+-Depleted Environment. | |
Myeloid cell sirtuin-1 expression does not alter host immune responses to Gram-negative endotoxemia or Gram-positive bacterial infection | |
n99800061 | |
The NAD(+)/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling | |
The NAD+-dependent deacetylase SIRT1 modulates CLOCK-mediated chromatin remodeling and circadian control | |
NAD+ supplementation rejuvenates aged gut adult stem cells. | |
Neurogenesis directed by Sirt1. | |
Neuronal SIRT1 regulates endocrine and behavioral responses to calorie restriction | |
Nucleolar localization of the Werner syndrome protein in human cells | |
Passage through stationary phase advances replicative aging in Saccharomyces cerevisiae | |
The place of genetics in ageing research. | |
Rate of brain aging and APOE ε4 are synergistic risk factors for Alzheimer's disease | |
Reonarudo garente : Chōju idenshi o tokiakasu | |
Repeat dose NRPT (nicotinamide riboside and pterostilbene) increases NAD+ levels in humans safely and sustainably: a randomized, double-blind, placebo-controlled study | |
A role for SIR-2.1 regulation of ER stress response genes in determining C. elegans life span | |
The role of calorie restriction and SIRT1 in prion-mediated neurodegeneration | |
The Saccharomyces cerevisiae Hap5p homolog from fission yeast reveals two conserved domains that are essential for assembly of heterotetrameric CCAAT-binding factor | |
Safety Assessment of High-Purity, Synthetic Nicotinamide Riboside (NR-E) in a 90-Day Repeated Dose Oral Toxicity Study, With a 28-Day Recovery Arm | |
Science fact and the SENS agenda. What can we reasonably expect from ageing research? | |
SIRT1 activates MAO-A in the brain to mediate anxiety and exploratory drive | |
SIRT1 deacetylase in aging-induced neuromuscular degeneration and amyotrophic lateral sclerosis | |
The SIRT1 deacetylase suppresses intestinal tumorigenesis and colon cancer growth | |
SIRT1 deacetylates and positively regulates the nuclear receptor LXR | |
SIRT1 inhibits transforming growth factor beta-induced apoptosis in glomerular mesangial cells via Smad7 deacetylation | |
SirT1 is required in the male germ cell for differentiation and fecundity in mice | |
Sirt1 mediates neuroprotection from mutant huntingtin by activation of the TORC1 and CREB transcriptional pathway | |
SIRT1 promotes differentiation of normal human keratinocytes. | |
SIRT1 protects against α-synuclein aggregation by activating molecular chaperones | |
SIRT1 regulates differentiation of mesenchymal stem cells by deacetylating β-catenin. | |
Sirt1 regulates insulin secretion by repressing UCP2 in pancreatic beta cells | |
SIRT1 shows no substrate specificity in vitro | |
SIRT1 suppresses beta-amyloid production by activating the alpha-secretase gene ADAM10. | |
SIRT1 suppresses the epithelial-to-mesenchymal transition in cancer metastasis and organ fibrosis | |
SIRT1 transgenic mice show phenotypes resembling calorie restriction | |
SIRT2 ablation has no effect on tubulin acetylation in brain, cholesterol biosynthesis or the progression of Huntington's disease phenotypes in vivo | |
SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells | |
SIRT5 Deacetylates carbamoyl phosphate synthetase 1 and regulates the urea cycle | |
Sirtuin 1 Promotes Deacetylation of Oct4 and Maintenance of Naive Pluripotency. | |
Sirtuins at a glance. | |
Small-molecule allosteric activators of sirtuins | |
SnapShot: sirtuins, NAD, and aging. | |
Superoxide dismutase 1 knock-down induces senescence in human fibroblasts | |
Telomere shortening exposes functions for the mouse Werner and Bloom syndrome genes | |
Telomeres, the nucleolus and aging | |
Tissue-specific regulation of SIRT1 by calorie restriction | |
Urea cycle regulation by mitochondrial sirtuin, SIRT5. | |
レオナルド・ガレンテ : 「長寿遺伝子」を解き明かす |