Richard J Youle US-amerikanischer Neurobiologe und Molekularbiologe
Youle, Richard J.
Youle, Richard.
VIAF ID: 86357020 (Personal)
Permalink: http://viaf.org/viaf/86357020
Preferred Forms
- 100 0 _ ‡a Richard J Youle ‡c US-amerikanischer Neurobiologe und Molekularbiologe
- 200 _ | ‡a Youle ‡b Richard J.
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- 100 1 _ ‡a Youle, Richard
- 100 1 _ ‡a Youle, Richard J.
- 100 1 _ ‡a Youle, Richard J.
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4xx's: Alternate Name Forms (6)
Works
Title | Sources |
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The accumulation of misfolded proteins in the mitochondrial matrix is sensed by PINK1 to induce PARK2/Parkin-mediated mitophagy of polarized mitochondria | |
Anti-apoptotic MCL-1 localizes to the mitochondrial matrix and couples mitochondrial fusion to respiration | |
Atypical mitochondrial fission upon bacterial infection | |
Bax activates endophilin B1 oligomerization and lipid membrane vesiculation | |
Bcl-x(L) retrotranslocates Bax from the mitochondria into the cytosol | |
Bcl-x(L) sequesters its C-terminal membrane anchor in soluble, cytosolic homodimers | |
Bid, but not Bax, regulates VDAC channels. | |
Cell biology: Form follows function for mitochondria. | |
Characterization of the membrane-inserted C-terminus of cytoprotective BCL-XL. | |
Chemogenomic profiling of endogenous PARK2 expression using a genome-edited coincidence reporter | |
Conformation of BCL-XL upon Membrane Integration | |
Control of mitochondrial permeability by Bcl-2 family members | |
Coupling mitochondrial and cell division | |
The cytokine, granulocyte-macrophage colony-stimulating factor (GM-CSF), can deliver Bcl-XL as an extracellular fusion protein to protect cells from apoptosis and retain differentiation induction | |
Cytomegalovirus cell death suppressor vMIA blocks Bax- but not Bak-mediated apoptosis by binding and sequestering Bax at mitochondria | |
Cytomegalovirus proteins vMIA and m38.5 link mitochondrial morphogenesis to Bcl-2 family proteins | |
Endosomal Rab cycles regulate Parkin-mediated mitophagy. | |
Endosome fusion induced by diphtheria toxin translocation domain | |
Fifth international Meeting on Ribonucleases, 1999: | |
Fluorescence-based ATG8 sensors monitor localization and function of LC3/GABARAP proteins. | |
Guidelines for the use and interpretation of assays for monitoring autophagy | |
High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy | |
Hsp90-Cdc37 chaperone complex regulates Ulk1- and Atg13-mediated mitophagy | |
IBRDC2, an IBR-type E3 ubiquitin ligase, is a regulatory factor for Bax and apoptosis activation | |
Instability of the mitofusin Fzo1 regulates mitochondrial morphology during the mating response of the yeast Saccharomyces cerevisiae | |
Loss of MARCH5 mitochondrial E3 ubiquitin ligase induces cellular senescence through dynamin-related protein 1 and mitofusin 1 | |
Loss of TAX1BP1-Directed Autophagy Results in Protein Aggregate Accumulation in the Brain | |
Make or break for mitochondria | |
Mechanisms of mitophagy | |
Mff is an essential factor for mitochondrial recruitment of Drp1 during mitochondrial fission in mammalian cells | |
MiT/TFE transcription factors are activated during mitophagy downstream of Parkin and Atg5 | |
Mitochondria, inflammation and Parkinson's disease | |
The mitochondrial E3 ubiquitin ligase MARCH5 is required for Drp1 dependent mitochondrial division | |
Mitochondrial fission and fusion mediators, hFis1 and OPA1, modulate cellular senescence | |
Mitochondrial fission facilitates the selective mitophagy of protein aggregates. | |
Mitochondrial Rab GAPs govern autophagosome biogenesis during mitophagy | |
Mitochondrial release of AIF and EndoG requires caspase activation downstream of Bax/Bak-mediated permeabilization | |
Mutations in Fis1 disrupt orderly disposal of defective mitochondria | |
Neurodegeneration: Trouble in the cell's powerhouse | |
Neurolastin, a Dynamin Family GTPase, Regulates Excitatory Synapses and Spine Density | |
Neurolastin, a dynamin family GTPase, translocates to mitochondria upon neuronal stress and alters mitochondrial morphology in vivo | |
Novel structure of the N terminus in yeast Fis1 correlates with a specialized function in mitochondrial fission. | |
Outer mitochondrial membrane protein degradation by the proteasome | |
p62/SQSTM1 is required for Parkin-induced mitochondrial clustering but not mitophagy; VDAC1 is dispensable for both | |
Parkin and PINK1 mitigate STING-induced inflammation | |
Parkin-induced mitophagy in the pathogenesis of Parkinson disease | |
Parkin overexpression selects against a deleterious mtDNA mutation in heteroplasmic cybrid cells | |
Phosphorylation of OPTN by TBK1 enhances its binding to Ub chains and promotes selective autophagy of damaged mitochondria | |
PINK1 and Parkin flag Miro to direct mitochondrial traffic | |
PINK1 drives Parkin self-association and HECT-like E3 activity upstream of mitochondrial binding | |
PINK1 is degraded through the N-end rule pathway | |
PINK1 is selectively stabilized on impaired mitochondria to activate Parkin | |
PINK1/Parkin Influences Cell Cycle by Sequestering TBK1 at Damaged Mitochondria, Inhibiting Mitosis | |
PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activity | |
PINK1 rendered temperature sensitive by disease-associated and engineered mutations. | |
Reciprocal Roles of Tom7 and OMA1 during Mitochondrial Import and Activation of PINK1 | |
Role of membrane association and Atg14-dependent phosphorylation in beclin-1-mediated autophagy | |
The role of mitochondria in apoptosis*. | |
Role of PINK1 binding to the TOM complex and alternate intracellular membranes in recruitment and activation of the E3 ligase Parkin | |
Sequestration and autophagy of mitochondria do not cut proteins across the board | |
The soluble form of Bax regulates mitochondrial fusion via MFN2 homotypic complexes | |
The solution structure of human mitochondria fission protein Fis1 reveals a novel TPR-like helix bundle | |
Spatiotemporal Control of ULK1 Activation by NDP52 and TBK1 during Selective Autophagy | |
STING induces LC3B lipidation onto single-membrane vesicles via the V-ATPase and ATG16L1-WD40 domain | |
Structural mechanism of Bax inhibition by cytomegalovirus protein vMIA | |
A systematic search for endoplasmic reticulum (ER) membrane-associated RING finger proteins identifies Nixin/ZNRF4 as a regulator of calnexin stability and ER homeostasis | |
Targeting mitochondrial dysfunction: role for PINK1 and Parkin in mitochondrial quality control | |
The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy | |
Ubiquitin ligase RNF167 regulates AMPA receptor-mediated synaptic transmission | |
ULK complex organization in autophagy by a C-shaped FIP200 N-terminal domain dimer | |
Vps13D Encodes a Ubiquitin-Binding Protein that Is Required for the Regulation of Mitochondrial Size and Clearance. |