Christopoulos, Arthur.
Arthur Christopoulos Australian pharmacologist and toxicologist
Christopoulos, Arthur, 1950-
VIAF ID: 61805961 (Personal)
Permalink: http://viaf.org/viaf/61805961
Preferred Forms
- 100 0 _ ‡a Arthur Christopoulos ‡c Australian pharmacologist and toxicologist
- 200 _ | ‡a Christopoulos ‡b Arthur
- 100 1 _ ‡a Christopoulos, Arthur
- 100 1 _ ‡a Christopoulos, Arthur
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- 100 1 _ ‡a Christopoulos, Arthur (sparse)
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- 100 1 _ ‡a Christopoulos, Arthur
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4xx's: Alternate Name Forms (6)
Works
Title | Sources |
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Biomedical applications of computer modeling | |
Fitting models to biological data using linear and nonlinear regression : a practical guide to curve fitting | |
International Union of Pharmacology Committee on Receptor Nomenclature and Drug Classification. XXXVIII. Update on terms and symbols in quantitative pharmacology | |
Involvement of the sigma1 (sigma1) receptor in the anti-amnesic, but not antidepressant-like, effects of the aminotetrahydrofuran derivative ANAVEX1-41. | |
Isoform-Specific Biased Agonism of Histamine H3 Receptor Agonists | |
Ligand-Dependent Modulation of G Protein Conformation Alters Drug Efficacy. | |
Ligand-Independent Adenosine A2B Receptor Constitutive Activity as a Promoter of Prostate Cancer Cell Proliferation | |
Mechanisms of ERK1/2 regulation by seven-transmembrane-domain receptors. | |
Minireview: Signal bias, allosterism, and polymorphic variation at the GLP-1R: implications for drug discovery | |
Molecular basis for benzodiazepine agonist action at the type 1 cholecystokinin receptor. | |
Monash University, Professor Arthur Christopoulos - Researcher Profile website, viewed 15 May 2015 : | |
Murine GPRC6A Mediates Cellular Responses to L-Amino Acids, but Not Osteocalcin Variants | |
Muscarinic receptors | |
Novel GPCR paradigms at the μ-opioid receptor | |
Novel Irreversible Agonists Acting at the A1 Adenosine Receptor. | |
On the mechanism of interaction of potent surmountable and insurmountable antagonists with the prostaglandin D2 receptor CRTH2 | |
Overview of Receptor Allosterism | |
Pharmacological discrimination of calcitonin receptor: receptor activity-modifying protein complexes | |
Phase-plate cryo-EM structure of a class B GPCR-G-protein complex | |
Positive allosteric mechanisms of adenosine A<sub>1</sub> receptor-mediated analgesia | |
A Positive Allosteric Modulator of the Adenosine A1 Receptor Selectively Inhibits Primary Afferent Synaptic Transmission in a Neuropathic Pain Model | |
Prediction of Loops in G Protein-Coupled Receptor Homology Models: Effect of Imprecise Surroundings and Constraints. | |
Probing the molecular mechanism of interaction between 4-n-butyl-1-[4-(2-methylphenyl)-4-oxo-1-butyl]-piperidine (AC-42) and the muscarinic M(1) receptor: direct pharmacological evidence that AC-42 is an allosteric agonist | |
Prolonged calcitonin receptor signaling by salmon, but not human calcitonin, reveals ligand bias | |
Proposed Mode of Binding and Action of Positive Allosteric Modulators at Opioid Receptors | |
Quantification of functional selectivity at the human α(1A)-adrenoceptor. | |
Quantification of ligand bias for clinically relevant β2-adrenergic receptor ligands: implications for drug taxonomy. | |
RAMPs as drug targets | |
Recent advances in understanding GLP-1R (glucagon-like peptide-1 receptor) function. | |
Receptor expression modulates calcium-sensing receptor mediated intracellular Ca2+ mobilization | |
Relative affinity of angiotensin peptides and novel ligands at AT1 and AT2 receptors. | |
Reversible and specific extracellular antagonism of receptor-histidine kinase signaling | |
The role of kinetic context in apparent biased agonism at GPCRs | |
Role of the Second Extracellular Loop of the Adenosine A1 Receptor on Allosteric Modulator Binding, Signaling, and Cooperativity. | |
Roles of intraloops-2 and -3 and the proximal C-terminus in signalling pathway selection from the human calcium-sensing receptor. | |
Separation of on-target efficacy from adverse effects through rational design of a bitopic adenosine receptor agonist | |
Signalling bias in new drug discovery: detection, quantification and therapeutic impact. | |
A simple method for quantifying functional selectivity and agonist bias | |
Small molecule allosteric modulation of the glucagon-like Peptide-1 receptor enhances the insulinotropic effect of oxyntomodulin. | |
Small-molecule-biased formyl peptide receptor agonist compound 17b protects against myocardial ischaemia-reperfusion injury in mice. | |
Structural basis for modulation of a G-protein-coupled receptor by allosteric drugs. | |
Structural basis of receptor sulfotyrosine recognition by a CC chemokine: the N-terminal region of CCR3 bound to CCL11/eotaxin-1 | |
The structural determinants of the bitopic binding mode of a negative allosteric modulator of the dopamine D2 receptor. | |
Structural features embedded in G protein-coupled receptor co-crystal structures are key to their success in virtual screening | |
A Structure-Activity Relationship Study of Bitopic N6-Substituted Adenosine Derivatives as Biased Adenosine A1 Receptor Agonists. | |
Structure-activity relationships of privileged structures lead to the discovery of novel biased ligands at the dopamine D₂ receptor. | |
Structure of the adenosine-bound human adenosine A1 receptor–Gi complex | |
Structures of the human cholecystokinin 1 (CCK1) receptor bound to Gs and Gq mimetic proteins provide insight into mechanisms of G protein selectivity | |
The synthesis and biological evaluation of 2-amino-4,5,6,7,8,9-hexahydrocycloocta[b]thiophenes as allosteric modulators of the A1 adenosine receptor. | |
Synthesis and pharmacological profiling of analogues of benzyl quinolone carboxylic acid | |
Systematic analysis of factors influencing observations of biased agonism at the mu-opioid receptor. | |
Towards a structural understanding of allosteric drugs at the human calcium-sensing receptor | |
Towards tissue-specific pharmacology: insights from the calcium-sensing receptor as a paradigm for GPCR (patho)physiological bias | |
Tyrosine sulfation of chemokine receptor CCR2 enhances interactions with both monomeric and dimeric forms of the chemokine monocyte chemoattractant protein-1 (MCP-1) | |
Use of Cysteine Trapping to Map Spatial Approximations between Residues Contributing to the Helix N-capping Motif of Secretin and Distinct Residues within Each of the Extracellular Loops of Its Receptor | |
VCP746, a novel A1 adenosine receptor biased agonist, reduces hypertrophy in a rat neonatal cardiac myocyte model. |