Samuel Aparicio Canadian cancer genomics researcher
Aparício, Samuel
Aparicio, Samuel, 1963-
VIAF ID: 315223699 (Personal)
Permalink: http://viaf.org/viaf/315223699
Preferred Forms
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- 100 1 _ ‡a Aparicio, Samuel, ‡d 1963-
- 100 1 _ ‡a Aparício, Samuel
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- 100 0 _ ‡a Samuel Aparicio ‡c Canadian cancer genomics researcher
4xx's: Alternate Name Forms (1)
Works
Title | Sources |
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Are columnar cell lesions the earliest histologically detectable non-obligate precursor of breast cancer? | |
Atrophin controls developmental signaling pathways via interactions with Trithorax-like | |
Barcoding reveals complex clonal dynamics of de novo transformed human mammary cells. | |
Bimolecular complementation affinity purification (BiCAP) reveals dimer-specific protein interactions for ERBB2 dimers. | |
Bioinformatics studies on the complexity of splicing and gene expression | |
Breast cancer : from fundamental biology to therapeutic strategies | |
The breast cancer oncogene EMSY represses transcription of antimetastatic microRNA miR-31. | |
CDK12 regulates alternative last exon mRNA splicing and promotes breast cancer cell invasion. | |
Chemogenomic profiling of breast cancer patient-derived xenografts reveals targetable vulnerabilities for difficult-to-treat tumors | |
CLK-dependent exon recognition and conjoined gene formation revealed with a novel small molecule inhibitor | |
The clonal and mutational evolution spectrum of primary triple-negative breast cancers | |
Clonal Decomposition and DNA Replication States Defined by Scaled Single-Cell Genome Sequencing | |
Columnar cell lesions, mammographic density and breast cancer risk | |
Combined Use of Gene Expression Modeling and siRNA Screening Identifies Genes and Pathways Which Enhance the Activity of Cisplatin When Added at No Effect Levels to Non-Small Cell Lung Cancer Cells In Vitro. | |
ddClone: joint statistical inference of clonal populations from single cell and bulk tumour sequencing data. | |
Decoding Transcriptome Dynamics of Genome-Encoded Polyadenylation and Autoregulation with Small-Molecule Modulators of Alternative Polyadenylation | |
Discovery and Characterization of a Eukaryotic Initiation Factor 4A-3-Selective Inhibitor That Suppresses Nonsense-Mediated mRNA Decay. | |
Discovery of selective ATP-competitive eIF4A3 inhibitors. | |
Dissociation of solid tumor tissues with cold active protease for single-cell RNA-seq minimizes conserved collagenase-associated stress responses | |
Divergent modes of clonal spread and intraperitoneal mixing in high-grade serous ovarian cancer. | |
DNA barcoding reveals diverse growth kinetics of human breast tumour subclones in serially passaged xenografts | |
DNA methylation landscapes of 1538 breast cancers reveal a replication-linked clock, epigenomic instability and cis-regulation | |
Dynamics of breast-cancer relapse reveal late-recurring ER-positive genomic subgroups | |
Dynamics of genomic clones in breast cancer patient xenografts at single-cell resolution. | |
EMSY links the BRCA2 pathway to sporadic breast and ovarian cancer | |
Engineered in-vitro cell line mixtures and robust evaluation of computational methods for clonal decomposition and longitudinal dynamics in cancer. | |
Epiclomal: Probabilistic clustering of sparse single-cell DNA methylation data | |
Epidermal growth factor receptor (EGFR) is transcriptionally induced by the Y-box binding protein-1 (YB-1) and can be inhibited with Iressa in basal-like breast cancer, providing a potential target for therapy | |
Evolutionary concepts in biobanking - the BC BioLibrary | |
Examining the utility of patient-derived xenograft mouse models. | |
Expression microarray reproducibility is improved by optimising purification steps in RNA amplification and labelling | |
Frequent somatic transfer of mitochondrial DNA into the nuclear genome of human cancer cells | |
Fugu genome analysis provides evidence for a whole-genome duplication early during the evolution of ray-finned fishes | |
Gene regulatory network analysis defines transcriptome landscape with alternative splicing of human umbilical vein endothelial cells during replicative senescence | |
Genome co-amplification upregulates a mitotic gene network activity that predicts outcome and response to mitotic protein inhibitors in breast cancer | |
Genomic consequences of aberrant DNA repair mechanisms stratify ovarian cancer histotypes | |
High-Resolution Single-Cell DNA Methylation Measurements Reveal Epigenetically Distinct Hematopoietic Stem Cell Subpopulations | |
High-throughput microfluidic single-cell RT-qPCR | |
Higher serum PD-L1 level predicts increased overall survival with lapatinib versus trastuzumab in the CCTG MA.31 phase 3 trial | |
Human mammary cancer progression model recapitulates methylation events associated with breast premalignancy | |
Identification of a selective DDX3X inhibitor with newly developed quantitative high-throughput RNA helicase assays | |
Impact of MLL5 expression on decitabine efficacy and DNA methylation in acute myeloid leukemia. | |
Impact of serum HER2, TIMP-1, and CAIX on outcome for HER2+ metastatic breast cancer patients: CCTG MA.31 (lapatinib vs. trastuzumab). | |
The implications of clonal genome evolution for cancer medicine | |
Improving breast cancer survival analysis through competition-based multidimensional modeling | |
In vivo radioimaging of bradykinin receptor b1, a widely overexpressed molecule in human cancer | |
Insulin-like peptide 5 is an orexigenic gastrointestinal hormone | |
Integrative analysis of genome-wide loss of heterozygosity and monoallelic expression at nucleotide resolution reveals disrupted pathways in triple-negative breast cancer | |
Inter-observer reproducibility of HER2 immunohistochemical assessment and concordance with fluorescent in situ hybridization (FISH): pathologist assessment compared to quantitative image analysis | |
Interfaces of Malignant and Immunologic Clonal Dynamics in Ovarian Cancer | |
International network of cancer genome projects | |
JointSNVMix: a probabilistic model for accurate detection of somatic mutations in normal/tumour paired next-generation sequencing data | |
Lapatinib or Trastuzumab Plus Taxane Therapy for Human Epidermal Growth Factor Receptor 2-Positive Advanced Breast Cancer: Final Results of NCIC CTG MA.31. | |
Lessons learned from the application of whole-genome analysis to the treatment of patients with advanced cancers | |
The Life History of 21 Breast Cancers | |
Mll5 is required for normal spermatogenesis | |
Molecular alterations between the primary breast cancer and the subsequent locoregional/metastatic tumor | |
Mutational evolution in a lobular breast tumour profiled at single nucleotide resolution | |
A new genome-driven integrated classification of breast cancer and its implications | |
A novel SND1-BRAF fusion confers resistance to c-Met inhibitor PF-04217903 in GTL16 cells through [corrected] MAPK activation | |
Nucleic acid quantity and quality from paraffin blocks: defining optimal fixation, processing and DNA/RNA extraction techniques. | |
Opening Pandora's Box--the new biology of driver mutations and clonal evolution in cancer as revealed by next generation sequencing | |
p300 regulates p53-dependent apoptosis after DNA damage in colorectal cancer cells by modulation of PUMA/p21 levels | |
p53: a new kingpin in the stem cell arena | |
Patient-derived xenograft (PDX) models in basic and translational breast cancer research. | |
Pharmacological systems analysis defines EIF4A3 functions in cell-cycle and RNA stress granule formation | |
Probabilistic cell-type assignment of single-cell RNA-seq for tumor microenvironment profiling | |
The RNA helicase DDX39B and its paralog DDX39A regulate androgen receptor splice variant AR-V7 generation | |
Robust high-performance nanoliter-volume single-cell multiple displacement amplification on planar substrates | |
Scalable whole-genome single-cell library preparation without preamplification | |
Solution NMR structure and histone binding of the PHD domain of human MLL5. | |
The somatic mutation profiles of 2,433 breast cancers refines their genomic and transcriptomic landscapes | |
Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin | |
Systematic analysis of challenge-driven improvements in molecular prognostic models for breast cancer | |
Systematic analysis of somatic mutations impacting gene expression in 12 tumour types | |
TDP1 and PARP1 deficiency are cytotoxic to rhabdomyosarcoma cells | |
TP53 mutation spectrum in breast cancer is subtype specific and has distinct prognostic relevance | |
Transcriptome analysis of the normal human mammary cell commitment and differentiation process | |
A tumor DNA complex aberration index is an independent predictor of survival in breast and ovarian cancer | |
Tumor heterogeneity: next-generation sequencing enhances the view from the pathologist's microscope | |
Ubiquitin-mediated DNA damage response is synthetic lethal with G-quadruplex stabilizer CX-5461 | |
Up-regulation of the interferon-related genes in BRCA2 knockout epithelial cells | |
Whole-Genome Shotgun Assembly and Analysis of the Genome of Fugu rubripes | |
Znaczenie klonalnej ewolucji genomu dla medycyny nowotworów | |
ZNF703 is a common Luminal B breast cancer oncogene that differentially regulates luminal and basal progenitors in human mammary epithelium |