Zachary A Knight physiologist, researcher
Knight, Zachary A.
VIAF ID: 235155044715272520004 (Personal)
Permalink: http://viaf.org/viaf/235155044715272520004
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- 100 0 _ ‡a Zachary A Knight ‡c physiologist, researcher
4xx's: Alternate Name Forms (2)
Works
Title | Sources |
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Ablation of AgRP neurons impairs adaption to restricted feeding | |
Ablation of PI3K blocks BCR-ABL leukemogenesis in mice, and a dual PI3K/mTOR inhibitor prevents expansion of human BCR-ABL+ leukemia cells | |
Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2 | |
Activity of the p110-alpha subunit of phosphatidylinositol-3-kinase is required for activation of epithelial sodium transport | |
Basal subtype and MAPK/ERK kinase (MEK)-phosphoinositide 3-kinase feedback signaling determine susceptibility of breast cancer cells to MEK inhibition | |
Characterization of structurally distinct, isoform-selective phosphoinositide 3'-kinase inhibitors in combination with radiation in the treatment of glioblastoma | |
Chemical genetics: where genetics and pharmacology meet | |
A chemical screen in diverse breast cancer cell lines reveals genetic enhancers and suppressors of sensitivity to PI3K isoform-selective inhibition. | |
A critical role for mTORC1 in erythropoiesis and anemia | |
Design of drug-resistant alleles of type-III phosphatidylinositol 4-kinases using mutagenesis and molecular modeling | |
Discovery of drug-resistant and drug-sensitizing mutations in the oncogenic PI3K isoform p110 alpha | |
Discovery of dual inhibitors of the immune cell PI3Ks p110delta and p110gamma: a prototype for new anti-inflammatory drugs | |
Downregulation of MYCN through PI3K Inhibition in Mouse Models of Pediatric Neural Cancer | |
Dual inhibition of PI3Kalpha and mTOR as an alternative treatment for Kaposi's sarcoma | |
A dual phosphoinositide-3-kinase alpha/mTOR inhibitor cooperates with blockade of epidermal growth factor receptor in PTEN-mutant glioma | |
A dual PI3 kinase/mTOR inhibitor reveals emergent efficacy in glioma | |
Dynamics of Gut-Brain Communication Underlying Hunger | |
Effect of combined DNA repair inhibition and G2 checkpoint inhibition on cell cycle progression after DNA damage | |
EGFR signals to mTOR through PKC and independently of Akt in glioma | |
For a PDK1 inhibitor, the substrate matters. | |
The Forebrain Thirst Circuit Drives Drinking through Negative Reinforcement | |
Genetic or pharmaceutical blockade of p110delta phosphoinositide 3-kinase enhances IgE production | |
HIV-1 Nef assembles a Src family kinase-ZAP-70/Syk-PI3K cascade to downregulate cell-surface MHC-I. | |
Hyperleptinemia is required for the development of leptin resistance | |
Identification of preoptic sleep neurons using retrograde labelling and gene profiling | |
Isoform-selective phosphoinositide 3'-kinase inhibitors inhibit CXCR4 signaling and overcome stromal cell-mediated drug resistance in chronic lymphocytic leukemia: a novel therapeutic approach | |
Isoform-specific phosphoinositide 3-kinase inhibitors from an arylmorpholine scaffold | |
Linking smell to metabolism and aging | |
Maintenance of hormone-sensitive phosphoinositide pools in the plasma membrane requires phosphatidylinositol 4-kinase IIIalpha | |
Making sense of the sensory regulation of hunger neurons | |
A membrane capture assay for lipid kinase activity | |
Molecular profiling of neurons based on connectivity | |
Neural circuits underlying thirst and fluid homeostasis | |
A novel pseudoknot element is essential for the action of a yeast telomerase | |
Obesity causes selective and long-lasting desensitization of AgRP neurons to dietary fat | |
A pharmacological map of the PI3-K family defines a role for p110alpha in insulin signaling | |
Phosphospecific proteolysis for mapping sites of protein phosphorylation | |
PI-103, a dual inhibitor of Class IA phosphatidylinositide 3-kinase and mTOR, has antileukemic activity in AML. | |
PIK3CA cooperates with other phosphatidylinositol 3'-kinase pathway mutations to effect oncogenic transformation | |
Re-examination of Dietary Amino Acid Sensing Reveals a GCN2-Independent Mechanism | |
Regulation of Body Temperature by the Nervous System. | |
A remodelled protease that cleaves phosphotyrosine substrates | |
Sensory detection of food rapidly modulates arcuate feeding circuits | |
Small molecule inhibitors of the PI3-kinase family | |
A Spotlight on Appetite | |
Sustained NPY signaling enables AgRP neurons to drive feeding | |
T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR. | |
Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases | |
Targeting the cancer kinome through polypharmacology | |
Targeting the gatekeeper residue in phosphoinositide 3-kinases | |
Thirst | |
Thirst neurons anticipate the homeostatic consequences of eating and drinking | |
To stabilize neutrophil polarity, PIP3 and Cdc42 augment RhoA activity at the back as well as signals at the front | |
Warm-Sensitive Neurons that Control Body Temperature |