ADAMTS13 T cell epitope identification in ThromboticThrombocytopenic Purpura patients. |
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ANALYSE DES REPERTOIRES AUTOREACTIFS DES ANTICORPS NATURELS CHEZ L'HOMME SAIN ET AU COURS DE PATHOLOGIES DYSIMMUNITAIRES |
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ANALYSIS OF SELF-REACTIVE REPERTOIRES OF NATURAL ANTIBODIES IN HEALTHY HUMAN AND DURING DYSIMMUNE DISEASES. |
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Anticorps catalytiques dirigés contre le FVIII dans différentes maladies chez l'homme |
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Catalytic antibodies directed against factor VIII in different human disorders. |
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Characterization of MHC-II-restricted antigen presentation mechanisms. |
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Control of the immune response directed against the therapeutic factor FVIII. |
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Creating and Use of an New Experimental Preclinical HLA Transgenic Mice Model to Mapping HLA-restricted T Cells Epitopes for Polyepitopes Vaccine Design |
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Etude de la réponse des lymphocytes T spécifiques de l'hormone humaine H2-relaxine et de modifications non-naturelles : perspectives pour la réduction de l'immunogénicité des protéines et peptides thérapeutiques |
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Exploitation d’un modèle expérimentale préclinique de souris HLA transgénique pour l’identification des épitopes T HLA-restreint afin de concevoir des vaccins poly-epitopiques. |
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Immunoprotective effect of von Willebrand factor towards therapeutic factor VIII in experimental haemophilia A. |
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Impact de l'IL-1β sur les lymphocytes Tfh et Tfr dans la réaction de centre germinatif physiologique et pathologique. |
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Impact of Antigen Density on the Binding Mechanism of IgG Antibodies |
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Important parameters for evaluation of antibody avidity by immunosorbent assay |
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Influence of the polyreactivity natural and led by the soluble immunoglobulins and the receivers of lymphocytes B on the modulation of the immune response. |
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Inhibition of differentiation, amplification, and function of human TH17 cells by intravenous immunoglobulin. |
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Inhibitor development. |
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Inhibitors-Recent insights |
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Innovating immune tolerance induction for haemophilia. |
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Insight into the mechanism of the acquired antibody auto-reactivity. |
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The interaction between factor H and VWF increases factor H cofactor activity and regulates VWF prothrombotic status |
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Intravenous gammaglobulin inhibits encephalitogenic potential of pathogenic T cells and interferes with their trafficking to the central nervous system, implicating sphingosine-1 phosphate receptor 1-mammalian target of rapamycin axis |
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Intravenous immunoglobulin abrogates dendritic cell differentiation induced by interferon-? present in serum from patients with systemic lupus erythematosus |
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Intravenous immunoglobulin in neurological disorders: a mechanistic perspective |
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Japanese encephalitis virus expands regulatory T cells by increasing the expression of PD-L1 on dendritic cells |
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Key insights to understand the immunogenicity of FVIII products. |
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Maternally transferred anti-factor VIII IgG reduce the anti-factor VIII humoral immune response in factor VIII-deficient mice. |
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Materno-Fetal Transfer of Preproinsulin Through the Neonatal Fc Receptor Prevents Autoimmune Diabetes |
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Methods for Posttranslational Induction of Polyreactivity of Antibodies |
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Modulation of human dendritic cell maturation and function by natural IgG antibodies |
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Molecular characterization of human B domain-specific anti-factor VIII monoclonal antibodies generated in transgenic mice |
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Monoclonal antibody and intravenous immunoglobulin therapy for rheumatic diseases: rationale and mechanisms of action. |
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Monoepitopic anti-FVIII T-cell response |
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Multitarget selection of catalytic antibodies with β-lactamase activity using phage display |
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Natural autoantibodies: immune homeostasis and therapeutic intervention |
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Natural Autoantibodies to Fcγ Receptors in Intravenous Immunoglobulins |
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Natural human polyreactive IgM induce apoptosis of lymphoid cell lines and human peripheral blood mononuclear cells. |
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Natural recognition repertoire and the evolutionary emergence of the combinatorial immune system |
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Novel cellular and molecular mechanisms of induction of immune responses by aluminum adjuvants |
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Parameters that influence the prediction of epidemiological benefits of more-effective tuberculosis vaccines, drugs, and diagnosis |
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Pathophysiology of catalytic antibodies |
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Peptide decoys selected by phage display block in vitro and in vivo activity of a human anti-FVIII inhibitor. |
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Polyreactivity of disease-associated anti-RBC IgG autoantibodies of patients with warm autoimmune haemolytic anaemia and natural anti-RBC IgG autoantibodies of healthy individuals |
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Predictive immunogenicity of Refacto AF. |
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Prevalence and gene characteristics of antibodies with cofactor-induced HIV-1 specificity. |
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Proteolytic antibodies activate factor IX in patients with acquired hemophilia. |
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"Rational vaccine design" for HIV should take into account the adaptive potential of polyreactive antibodies |
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Receptor of endocytosis for factor VIII by antigen presenting cells and role in the initiation of anti factor VIII immune response |
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Red blood cell transfusions are associated with alterations in self-reactive antibody repertoires of plasma IgM and IgG, independent of the presence of a specific immune response toward RBC antigens |
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[Regulation of autoreactivity by the idiotypic network and therapeutic modulation of autoimmunity by polyvalent intravenous immunoglobulins (IgIV)] |
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Relationship between natural and heme-mediated antibody polyreactivity. |
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Role of the intrinsic coagulation pathway in atherogenesis assessed in hemophilic apolipoprotein E knockout mice |
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Role of the proinflammatory environment in the immunogenicity of therapeutic factor viii in patients with severe hemophilia A. |
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Rôle physiopathologique des anticorps catalytiques et des anticorps polyréactifs |
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Selective impairment of serum antibody repertoires toward muscle and thymus antigens in patients with seronegative and seropositive myasthenia gravis |
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The self-reactive antibody repertoire of normal human serum IgM is acquired in early childhood and remains conserved throughout life |
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Sialylation may be dispensable for reciprocal modulation of helper T cells by intravenous immunoglobulin. |
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Les signaux de danger dans l'initiation de la réponse immunitaire contre le facteur VIII thérapeutique |
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Standardizing terms, definitions and concepts for describing and interpreting unwanted immunogenicity of biopharmaceuticals: recommendations of the Innovative Medicines Initiative ABIRISK consortium |
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Surveillance of antigen-presenting cells by CD4+ CD25+ regulatory T cells in autoimmunity: immunopathogenesis and therapeutic implications. |
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T cell-derived IL-22 amplifies IL-1β-driven inflammation in human adipose tissue: relevance to obesity and type 2 diabetes. |
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Therapeutic factor VIII does not trigger TLR1.2 and TLR2.6 signalling in vitro. |
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Thermodynamic analysis of the interaction of factor VIII with von Willebrand factor. |
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Thermodynamic stability contributes to immunoglobulin specificity |
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Towards the development of a gene therapy for Pompe disease : Characterization of the immune phenotype in Pompe disease and comparison of the therapeutic potential of gene therapy with the current standard of care |
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Transfert materno-foetal de protéines thérapeutiques par des IgGs modifiées et induction de tolérance immunitaire |
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Transition towards antigen-binding promiscuity of a monospecific antibody |
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Transplacental delivery of therapeutic proteins mediated by engineered IgGs and tolerance induction. |
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[Use of intravenous polyclonal immunoglobulins in autoimmune and inflammatory disorders]. |
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VWF protects FVIII from endocytosis by dendritic cells and subsequent presentation to immune effectors. |
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