Bioorganic chemistry : deoxysugars, polyketides and related classes: synthesis, biosynthesis, enzymes |
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Exploiting Chemical Diversity for Drug Discovery |
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Fermentation, purification, formulation, and pharmacological evaluation of a prolyl endopeptidase from Myxococcus xanthus: implications for Celiac Sprue therapy |
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A food-grade enzyme preparation with modest gluten detoxification properties |
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Gluten-sensitive enteropathy coincides with decreased capability of intestinal T cells to secrete IL-17 and IL-22 in a macaque model for celiac disease |
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Heterologous expression of diverse propionyl-CoA carboxylases affects polyketide production in Escherichia coli. |
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Heterologous expression, purification, refolding, and structural-functional characterization of EP-B2, a self-activating barley cysteine endoprotease |
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HEx: A heterologous expression platform for the discovery of fungal natural products. |
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Identification and analysis of multivalent proteolytically resistant peptides from gluten: implications for celiac sprue |
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In Vitro Reconstitution of Metabolic Pathways: Insights into Nature's Chemical Logic |
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INFORMATION ACCESS: Building A "GenBank" of the Published Literature |
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Inhibition of HLA-DQ2-mediated antigen presentation by analogues of a high affinity 33-residue peptide from alpha2-gliadin |
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Interferon-gamma released by gluten-stimulated celiac disease-specific intestinal T cells enhances the transepithelial flux of gluten peptides |
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Intestinal digestive resistance of immunodominant gliadin peptides |
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KIR<sup>+</sup>CD8<sup>+</sup> T cells suppress pathogenic T cells and are active in autoimmune diseases and COVID-19 |
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The loading and initial elongation modules of rifamycin synthetase collaborate to produce mixed aryl ketide products |
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Low-dose gluten challenge in celiac sprue: malabsorptive and antibody responses |
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Macrolactonization to 10-deoxymethynolide catalyzed by the recombinant thioesterase of the picromycin/methymycin polyketide synthase |
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Main chain hydrogen bond interactions in the binding of proline-rich gluten peptides to the celiac disease-associated HLA-DQ2 molecule. |
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Mechanism and engineering of polyketide chain initiation in fredericamycin biosynthesis |
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Mechanistic analysis of acyl transferase domain exchange in polyketide synthase modules |
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Metabolic engineering of a methylmalonyl-CoA mutase-epimerase pathway for complex polyketide biosynthesis in Escherichia coli |
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Modular polyketide synthases: Investigating intermodular communication using 6 deoxyerythronolide B synthase module 2. |
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A non-human primate model for gluten sensitivity |
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Noninflammatory gluten peptide analogs as biomarkers for celiac sprue |
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Nonproteinogenic amino acid building blocks for nonribosomal peptide and hybrid polyketide scaffolds |
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Orthogonal protein interactions in spore pigment producing and antibiotic producing polyketide synthases |
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Polyketide chain length control by chain length factor |
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Precursor directed biosynthesis of an orthogonally functional erythromycin analogue: selectivity in the ribosome macrolide binding pocket |
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Precursor-directed biosynthesis of epothilone in Escherichia coli |
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Prolyl endopeptidase-mediated destruction of T cell epitopes in whole gluten: chemical and immunological characterization |
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Putative efficacy and dosage of prolyl endopeptidase for digesting and detoxifying gliadin peptides |
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Quantitative analysis of the relative contributions of donor acyl carrier proteins, acceptor ketosynthases, and linker regions to intermodular transfer of intermediates in hybrid polyketide synthases |
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Rational design of combination enzyme therapy for celiac sprue. |
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Real-Time in Vivo Detection of H2O2 Using Hyperpolarized 13C-Thiourea. |
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Reconstituting modular activity from separated domains of 6-deoxyerythronolide B synthase |
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Reconstitution and characterization of a new desosaminyl transferase, EryCIII, from the erythromycin biosynthetic pathway |
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Regulation of the activities of the mammalian transglutaminase family of enzymes |
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Role of hypoxia-induced transglutaminase 2 in pulmonary artery smooth muscle cell proliferation |
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Roles of Conserved Active Site Residues in the Ketosynthase Domain of an Assembly Line Polyketide Synthase |
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A scaleable manufacturing process for pro-EP-B2, a cysteine protease from barley indicated for celiac sprue |
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Solution Structure and Backbone Dynamics of the Holo Form of the Frenolicin Acyl Carrier Protein |
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The Stanford Institute for Chemical Biology |
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Stereochemistry of reductions catalyzed by methyl-epimerizing ketoreductase domains of polyketide synthases |
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Stereospecificity of the dehydratase domain of the erythromycin polyketide synthase |
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Structural and Biochemical Studies of the Hedamycin Type II Polyketide Ketoreductase ( Hed KR): Molecular Basis of Stereo- and Regiospecificities |
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Structural and functional studies on SCO1815: a beta-ketoacyl-acyl carrier protein reductase from Streptomyces coelicolor A3(2). |
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Structural basis for HLA-DQ2-mediated presentation of gluten epitopes in celiac disease |
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Structure-activity relationships of semisynthetic mumbaistatin analogs |
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Structure and mechanism of the 6-deoxyerythronolide B synthase |
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Structure-based design of alpha-amido aldehyde containing gluten peptide analogues as modulators of HLA-DQ2 and transglutaminase 2. |
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Structure-based dissociation of a type I polyketide synthase module |
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Structure-Based Prototyping of Allosteric Inhibitors of Human Uridine/Cytidine Kinase 2 (UCK2) |
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Substrate tolerance of module 6 of the epothilone synthetase |
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Targeted gene replacements in a Streptomyces polyketide synthase gene cluster: role for the acyl carrier protein |
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Thioredoxin-1 Selectively Activates Transglutaminase 2 in the Extracellular Matrix of the Small Intestine: IMPLICATIONS FOR CELIAC DISEASE. |
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Tissue transglutaminase-mediated formation and cleavage of histamine-gliadin complexes: biological effects and implications for celiac disease. |
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Transglutaminase 2 in pulmonary and cardiac tissue remodeling in experimental pulmonary hypertension |
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Transglutaminase 2 undergoes a large conformational change upon activation |
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Tunable Enzymatic Synthesis of the Immunomodulator Lipid IVA To Enable Structure-Activity Analysis |
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Understanding and manipulating ganglioside biosynthesis, 2010: |
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Understanding substrate specificity of polyketide synthase modules by generating hybrid multimodular synthases. |
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An unprecedented dual antagonist and agonist of human Transglutaminase 2. |
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Use of transmission electron microscopy to identify nanocrystals of challenging protein targets |
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